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| Product Name | Recombinant Mouse KLK7 (carrier-free) |
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| Description | Kallikreins (KLKs) belong to a subgroup of secreted trypsin-like serine proteases within the S1 family (clan SA). So far, the human kallikrein family possesses 15 members and plays a key role in a wide range of processes, which include seminal clot liquefaction, skin desquamation, renal homeostasis, myelination, and enamelogenesis. In mice, repeated duplications of the KLK1 gene resulted in 24 paralogs. Mouse KLK7 was cloned from cDNA, which was derived from mouse tail. The murine cDNA showed 77% homology to human KLK7 cDNA. It had an open-reading frame encoding a protein of 249 amino acids with 82% amino acid sequence homology to the human protein. The murine protein has 21 amino acid signal peptide and a four amino acid propeptide ending with a tryptic cleavage site. The mature protein contains the conserved active site regions of serine proteinases. KLK7 participates in the desquamation process of the stratum corneum through the direct cleavage of corneodesmosin (CDSN) and desmoglein 1 (DSG1). CDSN and DSG1 are adhesive proteins of the extracellular part of the corneodesmosomes, which are the junctional structures that mediate corneocyte cohesion. They are also a key element of the functional protective barrier of human skin. Also, KLK7 regulates caspase-14 maturation during keratinocyte terminal differentiation. Through degradomics, the midkine, CYR61, and tenascin-C were identified as endogenous substrates for KLK7. In addition, KLK7 is overexpressed in human pancreatic, breast, cervical, and ovarian cancers. |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | BA |
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| Other Names | Kallikrein-7, mK7, Serine protease 6, Stratum corneum chymotryptic enzyme (SCCE) |
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| Gene, Accession, CAS # | Gene ID: 23993 |
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| Catalog # | 756908 |
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| Order / More Info | Recombinant Mouse KLK7 (carrier-free) from BIOLEGEND |
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| Product Specific References | n/a |
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