生物打印骨科材料,生物打印凝胶材料,ECM-BioInk,OsteoInk)

型号:ECM-BioInk,OsteoInk
价格:请致电:010-67529703
品牌:瑞士regenhu




 

BioInk® is hydrogel that promotes cell growth for different cells by providing cell

adhesion sites and

mimicking the natural extracellular matrix. Bioink® is available as a ready-to-use solution to print 3D
tissues models。

 



OsteoInk® is a ready-to-use calcium phosphate paste for structural engineering dedicated to
BioFactory® and 3DDiscovery® tissue printers. OsteoInk’s chemical composition (Hydroxyapatite /
tricalcium phosphate) is optimal for hard tissue engineering such than bone and cartilage. Threedimensional
printing enables freeform fabrication with controlled pore structure. BioFactory /3DDiscovery enables composite tissue printing by loading/filling the pores with bioactives such than cells /proteins /blood derivates/ hydrogels.

This portfolio is comprised of natural and synthetic hydrogels acting as extracellular-matrix environments to support cell growth (ECM-BioInk ™), biomaterials for scaffolding to mimic hard tissues (OsteoInk ™) and support materials (STARK ™).
OUR BIOMATERIALS AT A GLANCE


Biomaterials 
Application 
Characteristics 
HYDROGELS 
ECM-α BioInk ™ 
3D Cell culture, migration and proliferation assay 
Biosynthetic extracellular matrix with Low net charge 
ECM-β BioInk ™ 
Biosynthetic extracellular matrix with Mid net charge 
ECM-c BioInk ™ 
Biosynthetic charge extracellular matrix with High net charge 
ECM-f BioInk ™ 
Biosynthetic extracellular matrix with Low net charge Functionalized 
ECM-p BioInk ™ 
Biosynthetic extracellular matrix with Low net charge Functionalized 
SCAFFOLDING 
OsteoInk 
Calcium Phosphate biomaterial for hard tissue engineering 
Calcium phospahte formulation 
SUPPORT 
STARK 
Support material for Freeform Fabrication 
Silicon-based polymer 
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Biosynthetic Hydrogels

ECM-BioInk ™, is a peptide nanofiber 3-dimensional scaffold that promotes cell growth and migration. 
It utilizes specific peptides that self-assemble from ECM-BioInk ™ fluid precursors into highly intertwined hydrated peptide hydrogel fibres when presented with ionic strengths. By inducing a rapid transformation from solution to gel, a peptide nanofiber scaffold is generated.

The ECM-BioInk ™ portfolio contains 5 formulations that differ from each other in the electrical net charge which impacts the matrix stiffness and consequently cell proliferation capacity.


BioInk Datasheet

ECM- BioInk’s unique properties

  • Synthetic (highly reproducible with no batch to batch variation)
  • Adaptable matrix stiffness
  • Biological building blocks
  • Animal free
  • Mass transport of nutrients
  • Oxygen diffusion
  • Bulk distribution of proteins and grow factors
  • Optically transparent
  • Neutral pH
  • Ready to use with cells
  • Electrical net charge modulation
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ECM-α BioInk ™

ECM-βBioInk ™

ECM-p BioInk ™

By adjusting the concentration of the ECM-BioInk ™ solution, users can control the flexibility of the 3D architecture to meet their application′s specific needs. ECM-BioInk ™ is a unique human relevant, synthetic extracellular matrix in which scaffold interaction with cells and small molecules are driven by hydrogen and hydrophobic interactions

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SELECT YOUR ECM-BioInk ™ FORMULATION

BioInk Datasheet

Cell type 
ECM-α BioInk ™ 
ECM-β BioInk ™ 
ECM-c BioInk ™ 
ECM-f BioInk ™ 
ECM-p BioInk ™ 
Experiment 
Fibroblasts 
● 
● 
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● 
Proliferation, Migration 
Human Embryonic Stem Cells 
 
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● 
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Proliferation, 
Differentiation 
Human Induced Pluripotent Stem Cells 
 
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● 
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● 
Proliferation, 
Differentiation 
Human Mesenchemical Stem Cells 
● 
● 
● 
● 
● 
Proliferation, 
Differentiation 
Bone Marrow Derived Mesenchemial Stem Cells 
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● 
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Proliferation, 
Differentiation 
Adipose Tissue Derived Mesenchemical Stem Cells 
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● 
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Proliferation, 
Differentiation 
Human Haemopoetic Stem Cells 
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● 
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Proliferation, 
Differentiation 
Human Neuronal Stem Cells 
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● 
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Proliferation, 
Differentiation 
Cardiac Progenitor Cells 
● 
● 
● 
● 
● 
Proliferation, 
Differentiation 
Human Endothelial Cells 
● 
● 
● 


Proliferation, Migration 
Primary Neurons 
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Proliferation, Migration 
Cardiomyocytes 
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● 
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Proliferation, Migration 
Nucleus Pulposus Cells 
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Proliferation, Migration 
Hepatocytes 
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● 
Proliferation, Migration 
Chrondrocytes 
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Proliferation, Migration 
Myocytes 
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Proliferation, Migration 

Order 
Order 
Order 
Order 
Order 

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OSTEOINK™

CALCIUM PHOSPHATE MATERIAL FOR 3D TISSUE PRINTING

OsteoInk™ is a ready-to-use calcium phosphate paste for scaffolding and structural engineering. OsteoInk™ is a highly osteoconductive biomaterial close to the chemical composition of human bone. Dedicated to hard tissue engineering such as bone, cartilage or structural scaffold manufacturing, OsteoInk™ can be combined during the printing process with our biomaterial product portfolio (e.g ECM-BioInk ™) to create complex 3D tissue models. 
The uniqueness of BioFactory ™ and 3DDiscovery ™printers enables freeform fabrication of tissue models with controlled layers, pore structure and biological composition. It enables scientists to mimic nature by combining OsteoInk™ with hydrogels (natural or synthetic), bioactives, scaffolding or support materials.

FACTS

  • Designed for BioFactory ™ and 3DDiscovery ™tissue printers
  • Osteoconductive calcium phosphate material
  • For Research and Development
  • Available in 5cc cartridge
  • Can be combined with BioInk ™, STARK or any other type of bioactives and/or biomaterials
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BioInk ™

Biosynthetic extracellular matrix

BioInk ™ is a chemically-defined hydrogel to support growth of different cell types. It allows cell adhesion, mimics the natural extracellular matrix and is biodegradable. BioInk ™ is provided as a ready-to-use chemically-defined hydrogel to print 3D tissue models. Exclusively designed for regenHU’s BioFactory ™ and 3DDiscovery ™tissue and bio-printers.

A versatile, chemically-defined hydrogel, supporting cell attachment, growth, differentiation and migration. The BioInk ™ is suitable for long-term tissue cultivation (in vitro human dermis for up to 7 weeks).

Modular Matrix Tailored to the needs of your cells 
Combined with BioFactory ™ or 3DDiscovery ™tissue printers, you will be able to create composite tissue models in a layer-by-layer fashioning with spatial control of bioactive components (matrix, cells, proteins) and biomaterials.

BioInk Datasheet
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STARK™

3D SHAPE FIDELITY FOR BIOMIMICS | BIOPOLYMER FOR SCAFFOLDING SUPPORT

Creation of tissue models of complex bioarchitectures and overhanging structures, in single or composite materials, may require fugitive support materials that act as a temporary scaffold for the structure.

Especially in 3D cell culture & LifeScience applications where extracellular matrix materials (ECM) such as low-viscose hydrogels, collagens or similar are used to encapsulate and deliver bioactives, STARK™ biopolymer enables 3D shape fidelity and bioarchitecture control of cell-laden conceptions.

STARK™ is a biocompatible biopolymer dedicated to hard & soft tissue engineering with either a 3DDiscovery™ or BioFactory™ bioprinting platform. It can be used during the construction process in combination with BioInk ™ or OsteoInk™ or any natural or synthetic printable biomaterials.

FACTS

  • Designed for 3DDiscovery™ & BioFactory™ bioprinters
  • Cell friendly biocompatible support material, flexible/soft and controlled hardening
  • For Research & Development
  • Thermosensitive cross-linking
  • Can be combined with any printable biomaterial in single process approach
  • Exploit full potential with Bioprinting Software Suite (BioCAM™, BioCUT™)
  • Available in 3cc cartridges, ready to use single component cartridge