Athens Research & Technology;16-14-081416;Defensins, Alpha, Mixed from Human Neutrophils (HNP, Human Neutrophil Peptides)

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MW: <3,500
Extinction Coefficient: 2.95

Frozen in 1 M acetic acid.

Storage: -70°C or lower

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In general, defensins are small cysteine-rich cationic proteins found in both vertebrates and invertebrates. These mixed alpha defensins are purified from human neutrophils. These peptides are active in killing bacteria, fungi, and enveloped viruses, and therefore, enable the neutrophils to inactivate and destroy potential pathogens. Defensins damage or kill ingested microbes by penetrating the microbial's cell membrane by way of electrical attraction, and consequently forming pores in the membrane.

Ref: Gann et al. "Defensins: Natural Peptide Antibodies fo Human Neutrophils".

Protein concentration is determined using an extinction coefficient of 2.95 for a 0.1% solution.

Purity: >=95% by SDS-PAGE

Prepared from whole blood shown to be non reactive for HBsAg, anti-HCV, anti- HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose. For research or further manufacturing use only.

Product Citation:
Maeda T, Sakiyama T, Kanmura S, Hashimoto S, et al. 
Low concentrations of human neutrophil peptide ameliorate experimental murine colitis.
Int J Mol Med. 2016 Dec;38(6):1777-1785. Doi: 10.3892/ijmm.2016.2795. Epub 2016 Nov 3.