BMM 动态力学测试分析系统-DYNAMIC MECHANICAL ANALYSIS
-多载荷多物理场耦合微观力学性能原位测试系统

BMM 品牌的MachOne 型号的多功能微观生物力学测试分析系统模块化集成压缩、张力、剪切、摩擦、扭转和2D/3D压痕、3D轮廓及多力混合耦连测试的一体化微观力学测试装置。能对生物组织、聚合物、凝胶、生物材料、胶囊、粘合剂和食品进行精密可靠的机械刺激和表征。允许表征的机械性能包括刚度、强度、模量、粘弹性、塑性、硬度、附着力、肿胀和松弛位移控制运动，

该系统可以做具有动态机械特性测试分析功能，可以通过高分辨率的轴向（拉伸/压缩）或剪切（平面或扭转）组织材料的动态力学特性测试分析。这些特性通常用具有存储和损耗模量分量的复数动态模量表示。储能模量可以与材料的刚度相关联，而损耗模量与通过塑性变形，内部摩擦，相对分子运动，弛豫过程，相变，形态变化等导致的样品内能量的损失相关。动态特性提供了分子水平的信息，以了解材料的机械性能。动态机械性能的评估对于表征非弹性性能（例如，粘弹性或多孔弹性）的材料的表征te别有用，这些材料的性能会随频率而变化。

该系统是能集成压缩、张力、剪切、摩擦、扭转和2D/3D压痕、3D轮廓及多力混合耦连测试的一体化微观力学测试装置。能对生物组织、聚合物、凝胶、生物材料、胶囊、粘合剂和食品进行精密可靠的机械刺激和表征。允许表征的机械性能包括刚度、强度、模量、粘弹性、塑性、硬度、附着力、肿胀和松弛位移控制运动。

特点

1、适用样品范围广：

1.1、从骨等硬组织材料到脑组织、眼角膜等软组织材料

1.2、从粗椎间盘的样品到j细纤维丝

2、通高量压痕测试分析

2.1、三维法向压痕映射非平面样品整个表面的力学特性

2.2、48孔板中压痕测试分析

3、力学类型测试分析功能齐

模块化集成压缩、张力、剪切、摩擦、扭转、穿刺、摩擦和2D/3D压痕、3D表面轮廓、3D厚度等各种力学类型支持,微观结构表征及动态力学分析研究

4、高分辨率:

4.1、位移分辨率达0.1um

4.2、力分辨率达0.025mN

5、行程范围广：50-250mm

6、体积小巧、可放入培养箱内

7 、高变分辨率成像跟踪分析

8、多轴向、多力偶联刺激

9、活性组织电位分布测试分析

10、产品成熟，文献量达上千篇

Biomomentum Mach-1™ 是一款专为生物材料与软物质设计的多轴微观力学测试系统，作为动态力学分析仪（DMA），它能精确测量材料在周期性振荡载荷下的粘弹性特性。其核心优势在于将传统DMA的测量能力与独特的微观力学功能（如3D法向压痕绘图）结合在一个模块化平台上。

🎯 典型用途：主要测量哪些动态参数？

Mach-1™ 作为动态力学测试仪，主要用于表征材料的粘弹性（Viscoelasticity），这是生物组织和软材料（如软骨、水凝胶）的关键特性。

动态测试模式

核心原理

典型输出参数

典型应用场景

动态力学分析

对样品施加正弦振荡位移，测量其响应的动态力信号

储能模量（E' 或 G'）：存储的弹性
损耗模量（E'' 或 G''）：耗散的粘性
损耗因子（Tan δ）：阻尼特性

评估关节软骨的阻尼性能、仿生水凝胶的动态刚度、组织工程的力学功能

应力松弛测试

快速施加固定应变，测量应力的衰减过程

松弛时间（τ）
平衡模量

研究椎间盘、皮肤、韧带等组织的应力随时间衰减的行为

蠕变测试

施加恒定载荷，测量样品的变形随时间的变化

蠕变柔量
稳态蠕变速率

评估骨水泥的长期变形、椎间盘在恒定载荷下的压缩行为

多频率扫描

在一系列不同频率下进行DMA测试

主曲线（通过时温叠加原理构建）
频率依赖性图谱

研究组织的频率响应特性，模拟不同运动速度下的力学行为

📋 使用场景：哪些研究需要用到它？

Mach-1的动态力学功能主要应用于以下四大类研究场景：

骨科与关节生物学研究

评估关节软骨功能：这是最典型的应用。在模拟生理载荷的频率下（如0.01-10 Hz），对软骨进行动态压痕测试，其动态模量和Tan δ是评估其健康状态、检测早期骨关节炎（OA）退变的敏感指标。

研究半月板与椎间盘：测量这些承重组织在不同频率下的动态剪切模量和压缩模量，了解其在复杂力学环境下的功能。

组织工程与再生医学

工程化组织质检：对体外培养的工程化软骨、皮肤、肌腱等构建体进行无损动态力学测试，这是评估其是否具备移植功能的关键指标。

生物反应器模拟：可将系统置于培养箱内，在动态力学刺激下长期培养细胞/组织，研究力学环境对组织成熟和基质合成的影响。

生物材料与软物质研发

水凝胶与软组织仿生体：为组织工程支架、药物递送载体或医用粘合剂进行DMA表征，精确调控其粘弹性以匹配天然组织。

软物质物理研究：研究聚合物、胶体、食品等软物质的流变学特性和微观结构动力学。

小动物模型与基础医学研究

模式动物表型分析：例如，一项研究使用Mach-1对斑马鱼心脏进行动态力学测试（ excitation frequencies at 0.1, 1, 1.4, and 2 Hz），以评估体内生物电子植入物（eBICS）的功能，展示了其在活体微观力学研究中的独特能力。

✨ 亮点优势：为何选择Mach-1进行动态力学测试？

与传统的商业DMA相比，Mach-1在生命科学领域展现出独特的优势：

独特的力-电耦合模块

亮点：能够与机电测试腔室集成，在施加动态力学载荷的同时，原位测量样品（如软骨）产生的流动电位。这种独特的力-电耦合表征能力，为研究生物组织的功能提供了其他DMA无法比拟的视角。

生理环境兼容性

亮点：系统整体可放入标准细胞培养箱，测试腔室可充满PBS等生理盐水，在37°C、5% CO₂的液体环境下进行测试，完美模拟体内环境，确保细胞/组织在测试过程中的存活率。

超宽的力学范围和灵敏度

亮点：可处理的样品模量横跨3 Pa（极软组织）至 670 GPa（硬骨）。通过更换不同量程的传感器（力分辨率低至0.025 mN），既能精确表征柔软的脑组织或单根水凝胶纤维，也能测试高强度的骨材料。

独有的3D曲面法向压痕功能

亮点：Mach-1是全球唯一能在非平面、不规则的生物样品（如关节头）表面进行自动法向压痕测试的商业化系统。这一核心功能使其能精准评估在体或离体关节的真实功能。

模块化与未来可升级性

亮点：系统采用模块化设计，可随时添加多轴传感器、旋转台、高精度摄像头等硬件模块，以及DMA、3D绘图、多轴控制等软件插件，使其能随着研究需求的变化而不断升级，保护用户投资。

总的来说，Biomomentum Mach-1™ 不仅是一台性能卓越的微观动态力学分析仪，更是一个能无缝集成力-电耦合测试、生理环境模拟和三维曲面绘图的多功能生物力学研究平台。它尤其适合需要在一台设备上完成从材料静态压缩到动态粘弹性、从力学表征到电生理信号检测的综合性研究团队。

动态机械力学分析应用视频：

Dynamic mechanical Analysis
Testing Procedure Rubber
Testing Procedure Hydrogel
Analysis Procedure

典型文献：

Literature (18)

Injectable and degradable Poly(oligoethylene glycol methacrylate)-based hydrogels-synthetic versatility for improved biomaterial designBakaic E, Smeets N, Imbrogno S and Hoare TOral #327.3 on Friday, May 20 from 14:00 to 15:00 in room 524 during World Biomaterials Congress, Montreal, May 2016.

Introduction: Poly(ethylene glycol) (PEG)-based hydrogels are attractive biomaterials due to their hydrophilic, non-cytotoxic and non-immunogenic properties[1]. We recently reported on in situ-gelling PEG-analogue hydrogels based on poly(oligoethylene glycol methacrylate) (POEGMA) formed via rapid gelation of hydrazide and aldehyde-functionalized POEGMA oligomers upon mixing that overcome many...Read More

Biomechanical models for radial distance determination by the rat vibrissal systemBirdwell JA, Solomon JH, Thajchayapong M, Taylor MA, Cheely M, Towal RB, Conradt J and Hartmann MJJournal of neurophysiology, 98(4), 2439-2455. (2007)

Rats use active, rhythmic movements of their whirs to acquire tactile information about three-dimensional object features. There are no receptors along the length of the whir; therefore all tactile information must be mechanically transduced back to receptors at the whir base. This raises the question: how might the rat determine the radial contact position of an object along the whir?...Read More

Highly oriented in situ gelling nanocomposite hydrogels as tissue engineering scaffolds for promoting directional cell growthDe France K, Yager KG, Chan KJ, Hoare TR and Cranston EDPoster #P.0554 on Thursday, May 19 from 15:00 to 16:30 in room 220BCD (P3) during World Biomaterials Congress, Montreal, May 2016

Introduction: Patterned hydrogels and polymer scaffolds have attracted attention as platforms for directed cell growth due to the significant impacts cell alignment has on tissue regeneration, mechanical properties and various other cell behaviours[1],[2]. However, most currently reported platforms require lengthy micropatterning steps[3]-[10], limiting their clinical applicability in vitro....Read More

Fully injectable hydrazone-thiosuccinimide and hydrazone-disulfide interpenetrating polymer network hydrogels by kinetically orthogonal cross-linking of functionalized PNIPAM and PVP precurGilbert T and Hoare TPoster #P.0058 on Thursday, May 19 from 15:00 to 16:30 in room 220BCD (P1) during World Biomaterials Congress, Montreal, May 2016.

Introduction: IPNs are produced by interlocking two chemically distinct networks in each other’s free volume fraction. This interlocking and the potential for segregation of the IPNs into inhomogeneous domains can cause mechanical properties and microstructures distinct from single network controls. Prior IPNs reported as injectable (desired for minimally invasive delivery) were polymerized...Read More

Engineering degradable ''smart'' biomedical hydrogels on multiple length scalesHoare TOral #339.2 on Friday, May 20 from 16:30 to 18:30 in room 520B during World Biomaterials Congress, Montreal, May 2016

While multiple types of smart, environmentally-responsive materials have been explored for a variety of biomedical applications (e.g. drug delivery, tissue engineering, bioimaging, etc.), their ultimate clinical use has been hampered by their lack of biologically-relevant degradation as well as challenges regarding their non-surgical administration to the body. These factors have particularly limited...Read More

The Aortic Wrap Procedure - A Surgical Method of Treating Age-Related Aortic Dilatation and StiffnessIliopoulos JPhD Thesis, University of New South Wales, Sydney. (2006)

Introduction: There is progressive stiffening and dilatation of the aorta and large elastic arteries with aging as a result of the repetitive cyclic stress they are exposed to throughout life. Aortic stiffening has a number of detrimental effects including an increase in aortic pulse wave velocity and early wave reflection, isolated systolic hypertension, ventricular-vascular mismatch, impaired...Read More

Characterization of the effect of microfracture surgery and angle of incidence on the structural properties of femoral boneLiang LD, Wagner A, Steeds J, Hurtig M and Gordon KStudies by Undergraduate Researchers at Guelph, 7(1), 56-61. (2013)

Microfracture surgery is one of the most common treatment options for knee osteoarthritis, a chronic inflammatory disease of the knee joint. However, a recent study by Theodoropoulos et al. (2012) has shown that there are significant variations in the angle of surgical awl used by surgeons in microfracture surgery as well as in the rehabiliation regimen prescribed following surgery. The purpose of...Read More

The effect of terminal sterilization on structural and biophysical properties of a decellularized collagen-based scaffold; implications for stem cell adhesionMatuska AM and McFetridge PSJ Biomed Mater Res Part B, 2014, pp 1-10

Terminal sterilization induces physical and chemical changes in the extracellular matrix (ECM) of ex vivo-derived biomaterials due to their aggressive mechanism of action. Prior studies have focused on how sterilization affects the mechanical integrity of tissue-based biomaterials but have rarely characterized effects on early cellular interaction, which is indicative of the biological response. Using...Read More

Static and Dynamic Compression Application and Removal on the Intervertebral Discs of Growing RatsMenard AL, Grimard G, Massol E, Londono I, Moldovan F and Villemure IJournal of Orthopaedic Research Month 2015, pp.1-9. (2015)

Fusionless implants are used to correct pediatric progressive spinal deformities, most of them spanning the intervertebral disc. This study aimed at investigating the effects of in vivo static versus dynamic compression application and removal on discs of growing rats. A microloading device applied compression. 48 immature rats (28 d.o.) were divided into two groups (43d, 53d). Each group included...Read More

Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrateSeguin CA, Grynpas MD, Pilliar RM, Waldman SD and Kandel RASpine, 29(12), 1299-1306. (2004)

STUDY DESIGN: This study describes the formation of nucleus pulposus tissue using a novel tissue engineering approach. OBJECTIVES: To determine if a construct composed of nucleus pulposus tissue on the surface of a calcium polyphosphate substrate could be formed in vitro with properties similar to native nucleus pulposus tissue.

SUMMARY OF BACKGROUND DATA: There...Read More

ASTM F1717 - Standard Test Methods for Spinal Implant Constructs in a Vertebrectomy ModelASTM International, West Conshohocken, PA, 2015, www.astm.org

Significance and Use

5.1 Spinal implants are generally composed of several components which, when connected together, form a spinal implant assembly. Spinal implant assemblies are designed to provide some stability to the spine while arthrodesis takes place. These test methods outline standard materials and methods for the evaluation of different spinal implant assemblies so...Read More

MachOne - Dynamic Mechanical Testing (MA056-SOP04-D v1)Hadjab I and Quenneville EBMM Inc. Laval (QC), Canada, Effective Date: December 3rd, 2014

Purpose
This document describes a standard method to assess the frequency behavior of the dynamic mechanical properties of material through the complex Young’s (E*) or shear (G*) modulus using the MachOne mechanical tester. Analysis of the measurement results is part of a companion document (SW186-SOP04-D).

Scope
This method can be applied...Read More

MachOne Analysis - Extraction of the Complex Modulus Components Following Dynamic Mechanical Testing (SW186-SOP04-D v1)Hadjab I and Quenneville EBMM Inc. Laval (QC), Canada, Effective Date: December 3rd, 2014

Purpose
This procedure describes a method for the extraction of the complex modulus components (Young’s (E’ and E”) and shear (G’ and G”) modulus) following dynamic mechanical testing performed as per MA056-SOP04-D.

Scope
This procedure can be used with any MachOne result file resulting from dynamic mechanical testing on a sample...Read More

Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576

Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed non-invasive in vivo techniques, such as magnetic resonance elastography. Results of in vitro and in vivo work are compared, emphasizing the specificities...Read More

Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive ManufacturingDeng X, Attalla R, Sadowski LP, Chen M, Majcher MJ, Urosev I, Yin D-C, Selvaganapathy PR, Filipe CDM and Hoare TBiomacromolecules 2017, Published Online, doi: 10.1021/acs.biomac.7b01243

We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic crosslinking between 2-aminophenylboronic acid-functionalized hyaluronic acid and poly(vinyl alcohol) yields hydrogels that recover their mechanical integrity within one minute after cutting or shear under both neutral...Read More

In Situ Cross-Linking of Poly (vinyl alcohol)/Graphene Oxide–Polyethylene Glycol Nanocomposite Hydrogels as Artificial Cartilage Replacement: Intercalation Structure, Unconfined Compressive Behavior, and Biotribological BehaviorsMeng, Yeqiao; Ye, Lin; Coates, Phil; Twigg, PeterJ. Phys. Chem. C, 2018, 122 (5), pp 3157–3167 DOI: 10.1021/acs.jpcc.7b12465

Poly(vinyl alcohol) (PVA)/graphene oxide (GO) nanocomposite hydrogel as artificial cartilage replacement was prepared via freezing/thawing method by introducing polyethylene glycol (PEG). Efficient grafting of PVA molecules onto GO surface was realized by formation of hydrogen bonding, resulting in exfoliation and uniform distribution of GO in PVA matrix. By introduction of appropriate content of GO,...Read More

Growth and Characterization of Multicellular Spheroids in Cellulose Derived Hydrogels as an Artificial Three-Dimensional ScaffoldMelissa CampbellUniversity of Toronto

The Young’s modulus of each hydrogel was performed on a MachOne Mechanical tester (BMM Inc., QC) using cyclic compression and parallel plate geometry. The hydrogels for testing were pre-formed into disks measuring 3.25 mm in height by 14 mm in diameter. Compression was executed by applying 20% strain at a rate of 0.03 mm/s in the +z direction. The Young’s modulus of the hydrogels was...Read More

Experimental and finite element analyses of bone strains in the growing rat tibia induced by in vivo axial compressionTanvir Mustafy, Irène Londono, Isabelle VillemureJournal of the Mechanical Behavior of Biomedical Materials

The objective of this study was to develop and validate a voxel based F

典型测试材料：

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动态力学分析	对样品施加正弦振荡位移，测量其响应的动态力信号	储能模量（E' 或 G'）：存储的弹性损耗模量（E'' 或 G''）：耗散的粘性损耗因子（Tan δ）：阻尼特性	评估关节软骨的阻尼性能、仿生水凝胶的动态刚度、组织工程的力学功能
应力松弛测试	快速施加固定应变，测量应力的衰减过程	松弛时间（τ）平衡模量	研究椎间盘、皮肤、韧带等组织的应力随时间衰减的行为
蠕变测试	施加恒定载荷，测量样品的变形随时间的变化	蠕变柔量稳态蠕变速率	评估骨水泥的长期变形、椎间盘在恒定载荷下的压缩行为
多频率扫描	在一系列不同频率下进行DMA测试	主曲线（通过时温叠加原理构建）频率依赖性图谱	研究组织的频率响应特性，模拟不同运动速度下的力学行为

多功能多尺度动态力学分析系统，DYNAMIC MECHANICAL ANALYSIS system

BMM 动态力学测试分析系统-DYNAMIC MECHANICAL ANALYSIS-多载荷多物理场耦合微观力学性能原位测试系统

🎯 典型用途：主要测量哪些动态参数？

📋 使用场景：哪些研究需要用到它？

✨ 亮点优势：为何选择Mach-1进行动态力学测试？

动态机械力学分析应用视频：

典型文献：

Literature (18)

典型测试材料：

BMM 动态力学测试分析系统-DYNAMIC MECHANICAL ANALYSIS
-多载荷多物理场耦合微观力学性能原位测试系统