口腔摩擦质构感知测试系统

加拿大BMM MachOne多功能微观力学测试仪，可以用作口腔润滑摩擦力测试系统，口腔正畸动态摩擦力测试系统，口感摩擦力测试分析系统，口腔摩擦质构感知测试系统,食品质构感官摩擦力测试系统。

背景：

口腔摩擦被认为是口腔质构感官的一个重要机理，用来描述舌头与口腔上颚、舌头与食品之间相对运动和由此产生的触觉感官。

传统的食品流变学常常只能描述咀嚼初期的感官性质,而不能描述口腔加工过程的质构性质。近年来口腔摩擦被认为是口腔质构感官的重要机理。

该系统是能集成模块化压缩、张力、剪切、摩擦、扭转和2D/3D压痕、3D轮廓及多力混合耦连测试的一体化微观力学测试装置。能对生物组织、聚合物、凝胶、生物材料、胶囊、粘合剂和食品进行精密可靠的机械刺激和表征。允许表征的机械性能包括刚度、强度、模量、粘弹性、塑性、硬度、附着力、肿胀和松弛位移控制运动。

特点

1、适用样品范围广：

1.1、从骨等硬组织材料到脑组织、眼角膜等软组织材料

1.2、从粗椎间盘的样品到j细纤维丝

2、通高量压痕测试分析

2.1、三维法向压痕映射非平面样品整个表面的力学特性

2.2、48孔板中压痕测试分析

3、力学类型测试分析功能齐

模块化集成压缩、张力、剪切、摩擦、扭转、穿刺、摩擦和2D/3D压痕、3D表面轮廓、3D厚度等各种力学类型支持,微观结构表征及动态力学分析研究

4、高分辨率:

4.1、位移分辨率达0.1um

4.2、力分辨率达0.025mN

5、行程范围广：50-250mm

6、体积小巧、可放入培养箱内

7 、高变分辨率成像跟踪分析

8、多轴向、多力偶联刺激

9、活性组织电位分布测试分析

10、产品成熟，文献量达上千篇。

文献：

A study of saliva lubrication using a compliant oral mimic

G. Carpentera, S. Bozorgia, S. Vladescub, A.E. Forteb, C. Myantc, R.V. Potinenid, T. Reddyhoffb,?,

S.K. Baiere,f

Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and SlidingHsu FH, Hui AY, Chen AC, Lotz MK and Sah ROrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256

Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational motions between femoral condyle and tibia cartilage at least at the millimeter scale 2,3. The macroscale motions in the joint which translates...Read More

Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrand A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016

In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More

ASTM D1894 - Standard Test Method for Static and Kinetic Coefficients of Friction of Plastic Film and SheetingASTM International, West Conshohocken, PA, 2014, www.astm.org

Significance and Use

4.1 Measurements of frictional properties may be made on a film or sheeting specimen when sliding over itself or over another substance. The coefficients of friction are related to the slip properties of plastic films that are of wide interest in packaging applications. These methods yield empirical data for control purposes in film production. Correlation...Read More

ASTM F1538 - Standard Specification for Glass and Glass Ceramic Biomaterials for ImplantationASTM International, West Conshohocken, PA, 2009, www.astm.org

Abstract

This specification covers the material requirements and characterization techniques for glass and glass-ceramic biomaterials intended for use as bulk porous or powdered surgical implants, or as coatings on surgical devices, but not including drug delivery systems. Glass and glass-ceramic biomaterials should be evaluated thoroughly for biocompatibility before human use....Read More

ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular CartilageASTM International, West Conshohocken, PA, 2010, www.astm.org

Significance and Use

This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More

MachOne - Friction Testing on a Cartilage Disk or an Osteochondral (MA056-SOP08-D v2)Chartrand A and Quenneville EBMM Inc. Laval (QC), Canada, Effective Date: August 24th, 2015

Purpose
This procedure describes a standard method to realize a friction test on a cartilage disk or an osteochondral using the MachOne TM mechanical tester.

Scope
This procedure can be used for the ex vivo friction test using a planar sliding method on a cartilage disk or an osteochondral...Read More

MachOne Analysis - Extraction of Mechanical Parameters Following Friction Testing on a Cartilage Disk or an Osteochondral (SW186-SOP07-D v2)Chartrand A and Quenneville EBMM Inc. Laval (QC), Canada, Effective Date: August 24h, 2015

Purpose
This procedure describes a MatLab-based method to extract mechanical parameters from the MachOne result files generated following friction testing on a cartilage disk or an osteochondral as per MA056-SOP08-D.

Scope
This procedure based on a MatLab code can be applied using any MachOne result file obtained following a planar friction...Read More

Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011

Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting in an altered mechanical state within the tissues. Yet, it remains unclear how these surface changes affect the behaviour of embedded cells when the...Read More

Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)

There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte implantation (MACIs) using a collagen sponge as a chondrocyte delivery vehicle, the sponge membrane alone, and empty controls. A total of three distinct types of...Read More

Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21

OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. In the boundary mode of lubrication, load is supported by surface-to-surface contact, a feature that makes this mode particularly important for maintenance of the normally pristine articular surface. A boundary mode of lubrication is indicated by a kinetic friction coefficient...Read More

Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017

Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin s, to characterize cartilage degeneration. This study aims to determine whether the combination of instantaneous, relaxation and equilibrium mechanical properties and friction...Read More

Evaluation of genipin for stabilization of decellularized porcine cartilageElder S, Pinheiro A, Young C, Smith P and Wright EJ Orthop Res. 2016 Nov 18. doi: 10.1002/jor.23483

Abstract

We speculate that an acellular osteochondral xenograft may be a good alternative to allografts for repair of focal articular cartilage lesions. In order to make a xenograft resistant to enzymatic degradation and to prevent a chronic immune response it may beneficial to stabilize it through crosslinking. The concept is analogous to treatment of porcine bioprosthetic heart...Read More

Biomechanics and MechanoBiology of Human Cartilage ArticulationHsu FH, Alonso E, Raleigh AR, Saleh AA, Masuda K, Lotz MK, Chen AC and Sah ROrthopeadic Research Society Annual Meeting, 2016, Orlando, USA, Poster abstract 1428

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