多功能微观生物力学特性测试分析系统-SFA表面力仪，两个表面之间相互作用力测试系统，表面附着力测试分析系统，表面间静态动态力测试分析仪，表面间力学特性测试分析仪
型号:MachOne
联系人:李先生
联系电话:18618101725
品牌:BMM
多功能微观生物力学特性测试分析系统-
该系统是能集成压缩、张力、剪切、摩擦、扭转和2D/3D压痕、3D轮廓及多力混合耦连测试的一体化微观力学测试装置。能对生物组织、聚合物、凝胶、生物材料、胶囊、粘合剂和食品进行精密可靠的机械刺激和表征。允许表征的机械性能包括刚度、强度、模量、粘弹性、塑性、硬度、附着力、肿胀和松弛位移控制运动。
特点
1、适用样品范围广：
1.1、从骨等硬组织材料到脑组织、眼角膜等软组织材料
1.2、从粗椎间盘的样品到j细纤维丝
2、通高量压痕测试分析
◆wu需表面平坦，可在不规则表面压痕
◆压痕同时可测量厚度信息
◆压痕不要求压缩轴垂直于样品表面对齐
◆红宝石压头，坚固不易断
◆样品不需要从组织中收集
◆组织的破坏小
◆维持被测材料的机械环境及其与周围材料的相互作用
◆测试多个站点mapping
2.1、三维法向压痕映射非平面样品整个表面的力学特性
2.2、48孔板中压痕测试分析
3、力学类型测试分析功能齐
模块化集成压缩、张力、剪切、摩擦、扭转、穿刺、摩擦和2D/3D压痕、3D表面轮廓、3D厚度等各种力学类型支持,微观结构表征及动态力学分析研究
4、高分辨率:
4.1、位移分辨率达0.1um
4.2、力分辨率 达0.025mN
5、 行程范围广：50-250mm
6、体积小巧、可放入培养箱内
7 、高变分辨率成像跟踪分析
8、多轴向、多力偶联刺激
9、活性组织电位分布测试分析
10、产品成熟，文献量达 上千篇
该多功能微观生物力学特性测试分析系统之表面力测试分析功能特点
1、表面摩擦磨损系数测试
BMM 开发的软件使用垂直平台施加法向力，而其他阶段施加旋转或平移运动，则可以轻松确定摩擦系数和测试中涉及的力。
1.1、加拿大BMM MachOne多功能微观力学测试仪可以用作口腔润滑摩擦力测试系统
口腔正畸动态摩擦力测试系统，口感摩擦力测试分析系统，口腔摩擦质构感知测试系统,食品质构感官摩擦力测试系统。
背景：
口腔摩擦被认为是口腔质构感官的一个重要机理，用来描述舌头与口腔上颚、舌头与食品之间相对运动和由此产生的触觉感官。
传统的食品流变学常常只能描述咀嚼初期的感官性质,而不能描述口腔加工过程的质构性质。近年来口腔摩擦被认为是口腔质构感官的重要机理。
详细点击查看：http://www.bio-goods.com/products_bio/fabu/SupplyItem1575964540292.html1.2、软骨表面摩擦磨损测试
Needle Penetration and Friction Testing（针刺和摩擦测试）：
Friction Test on an Osteochondral （骨软骨核摩擦试验视频）：
2、剪切模量测试
关节软骨椎间盘的剪切测试
压缩，剪切和扭转
3、黏附粘合力测试分析(TACK ,ADHESIVE)：
★粘性水滴状试样夹具（环形初粘试验）
点与特点：
- 此零件设计坚固，可多年保持其完整性
- 与生理盐水溶液接触浸没式设计
- 易于组装和安装在测试仪上
- 由生物相容性材料制成
- 技术指标
- 材质：不锈钢304
- 长度：1英寸（平底）
- 直径：5 mm（扁探针）
- 重量调整为9.8 +/- 0.1 kPa（环形重量）
★用倒置探头测定胶粘剂压合粘结性
3.1、生物材料表面细胞附属物测试-----量化测量评估细胞与生物材料表面的附着力( the Attachment of Cells to Biomaterial Surfaces)
3.2、环形胶粘剂标准测试，
BMM 胶粘剂：
粘合剂是用于将两个或多个组件连接在一起的物质。 粘合剂的机械性能对于选择，设计和计算粘合剂粘合至关重要。
4、2D/3D表面轮廓测试（表面形貌及粗糙度测试分析）
BMM MachOne多功能微观生物力学特性测试分析系统通过与表面进行一系列非常轻的接触扫描表面来执行非破坏性表征。小的球形压头朝着表面放直到称重传感器检测到预定义的载荷（低至uN）。压头在次接触检测时的垂直位置是表面的局部高度。可以在各种硬度范围（几千帕至几百GPa）的样品上实现亚微米分辨率。该技术不受光学伪影的影响，可以在将样品浸入溶液中的情况下进行。
胫骨三维轮廓测试
BMM 摩擦磨损测试相关文献：
Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and SlidingHsu FH, Hui AY, Chen AC, Lotz MK and Sah ROrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256
Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational motions between femoral condyle and tibia cartilage at least at the millimeter scale 2,3. The macroscale motions in the joint which translates...Read More
Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrand A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016
In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More
ASTM D1894 - Standard Test Method for Static and Kinetic Coefficients of Friction of Plastic Film and SheetingASTM International, West Conshohocken, PA, 2014, www.astm.org
Significance and Use
4.1 Measurements of frictional properties may be made on a film or sheeting specimen when sliding over itself or over another substance. The coefficients of friction are related to the slip properties of plastic films that are of wide interest in packaging applications. These methods yield empirical data for control purposes in film production. Correlation...Read More
4.1 Measurements of frictional properties may be made on a film or sheeting specimen when sliding over itself or over another substance. The coefficients of friction are related to the slip properties of plastic films that are of wide interest in packaging applications. These methods yield empirical data for control purposes in film production. Correlation...Read More
ASTM F1538 - Standard Specification for Glass and Glass Ceramic Biomaterials for ImplantationASTM International, West Conshohocken, PA, 2009, www.astm.org
Abstract
This specification covers the material requirements and characterization techniques for glass and glass-ceramic biomaterials intended for use as bulk porous or powdered surgical implants, or as coatings on surgical devices, but not including drug delivery systems. Glass and glass-ceramic biomaterials should be evaluated thoroughly for biocompatibility before human use....Read More
This specification covers the material requirements and characterization techniques for glass and glass-ceramic biomaterials intended for use as bulk porous or powdered surgical implants, or as coatings on surgical devices, but not including drug delivery systems. Glass and glass-ceramic biomaterials should be evaluated thoroughly for biocompatibility before human use....Read More
ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular CartilageASTM International, West Conshohocken, PA, 2010, www.astm.org
Significance and Use
This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More
This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More
MachOne - Friction Testing on a Cartilage Disk or an Osteochondral (MA056-SOP08-D v2)Chartrand A and Quenneville EBMM Inc. Laval (QC), Canada, Effective Date: August 24th, 2015
Purpose
This procedure describes a standard method to realize a friction test on a cartilage disk or an osteochondral using the MachOne TM mechanical tester.
This procedure describes a standard method to realize a friction test on a cartilage disk or an osteochondral using the MachOne TM mechanical tester.
Scope
This procedure can be used for the ex vivo friction test using a planar sliding method on a cartilage disk or an osteochondral...Read More
This procedure can be used for the ex vivo friction test using a planar sliding method on a cartilage disk or an osteochondral...Read More
MachOne Analysis - Extraction of Mechanical Parameters Following Friction Testing on a Cartilage Disk or an Osteochondral (SW186-SOP07-D v2)Chartrand A and Quenneville EBMM Inc. Laval (QC), Canada, Effective Date: August 24h, 2015
Purpose
This procedure describes a MatLab-based method to extract mechanical parameters from the MachOne result files generated following friction testing on a cartilage disk or an osteochondral as per MA056-SOP08-D.
This procedure describes a MatLab-based method to extract mechanical parameters from the MachOne result files generated following friction testing on a cartilage disk or an osteochondral as per MA056-SOP08-D.
Scope
This procedure based on a MatLab code can be applied using any MachOne result file obtained following a planar friction...Read More
Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011
Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting in an altered mechanical state within the tissues. Yet, it remains unclear how these surface changes affect the behaviour of embedded cells when the...Read More
Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)
There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte implantation (MACIs) using a collagen sponge as a chondrocyte delivery vehicle, the sponge membrane alone, and empty controls. A total of three distinct types of...Read More
Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21
OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. In the boundary mode of lubrication, load is supported by surface-to-surface contact, a feature that makes this mode particularly important for maintenance of the normally pristine articular surface. A boundary mode of lubrication is indicated by a kinetic friction coefficient...Read More
Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017
Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin s, to characterize cartilage degeneration. This study aims to determine whether the combination of instantaneous, relaxation and equilibrium mechanical properties and friction...Read More
Evaluation of genipin for stabilization of decellularized porcine cartilageElder S, Pinheiro A, Young C, Smith P and Wright EJ Orthop Res. 2016 Nov 18. doi: 10.1002/jor.23483
Abstract
We speculate that an acellular osteochondral xenograft may be a good alternative to allografts for repair of focal articular cartilage lesions. In order to make a xenograft resistant to enzymatic degradation and to prevent a chronic immune response it may beneficial to stabilize it through crosslinking. The concept is analogous to treatment of porcine bioprosthetic heart...Read More
Biomechanics and MechanoBiology of Human Cartilage ArticulationHsu FH, Alonso E, Raleigh AR, Saleh AA, Masuda K, Lotz MK, Chen AC and Sah ROrthopeadic Research Society Annual Meeting, 2016, Orlando, USA, Poster abstract 1428
Introduction: During joint articulation, cartilage, particularly that near the articular surface, undergoes a complex combi
BMM 剪切模量测试文献：
Engineering of Hyaline Cartilage with a Calcified Zone Using Bone Marrow Stromal CellsLee WD, Hurtig MB, Pilliar RM, Stanford WL and Kandel RAOsteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.010
In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the movement of the joint and prevent the delamination of tissue-engineered cartilage. Previous approaches to create the ZCC at the cartilage-substrate interface...Read More
The shear mechanical properties of diabetic and non-diabetic plantar soft tissuePai S and Ledoux WRJournal of biomechanics, 45(2), 364-370. (2012)
Changes in the plantar soft tissue shear properties may contribute to ulceration in diabetic patients, however, little is known about these shear parameters. This study examines the elastic and viscoelastic shear behavior of both diabetic and non-diabetic plantar tissue. Previously compression tested plantar tissue specimens (n = 54) at six relevant plantar locations (hallux, first, third, and fifth...Read More
Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrand A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016
In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More
ASTM C273/C273M - Standard Test Method for Shear Properties of Sandwich MaterialsASTM International, West Conshohocken, PA, 2016, www.astm.org
Significance and Use
5.1 The shear properties are fundamental properties that are used in the design of sandwich panels. This test method provides information on the force-deflection behavior of sandwich constructions or s when loaded in shear parallel to the plane of the facings. From a complete force-deflection curve, it is possible to compute shear stress at...Read More
5.1 The shear properties are fundamental properties that are used in the design of sandwich panels. This test method provides information on the force-deflection behavior of sandwich constructions or s when loaded in shear parallel to the plane of the facings. From a complete force-deflection curve, it is possible to compute shear stress at...Read More
ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular CartilageASTM International, West Conshohocken, PA, 2010, www.astm.org
Significance and Use
This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More
This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More
MachOne - Shear Testing on a Cartilage Disk or an Osteochondral (MA056-SOP07-D v2)Tessier J and Quenneville EBMM Inc. Laval (QC), Canada, Effective Date: August 25th, 2015
Purpose
This procedure describes a standard method to realize a planar or a torsion shear test on an articular cartilage disk or an osteochondral using the MachOneTMmechanical tester.
This procedure describes a standard method to realize a planar or a torsion shear test on an articular cartilage disk or an osteochondral using the MachOneTMmechanical tester.
Scope
This procedure can be used for the ex vivo planar or torsion test on an articular cartilage or an osteochondral . It is highly...Read More
MachOne Analysis - Extraction of Mechanical Parameters Following Shear Testing on a Cartilage Disk or an Osteochondral (SW186-SOP06-D v1)Lavallée APBMM Inc. Laval (QC), Canada, Effective Date: August 19th, 2015
Purpose
This procedure describes a method to extract mechanical parameters from MachOne result files generated following shear testing on a cartilage disk or an osteochondral as per MA056-SOP07-D.
This procedure describes a method to extract mechanical parameters from MachOne result files generated following shear testing on a cartilage disk or an osteochondral as per MA056-SOP07-D.
Scope
This procedure can be applied using any MachOne result file obtained following a planar shear or a torsion test on a sample. Some...Read More
Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011
Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting in an altered mechanical state within the tissues. Yet, it remains unclear how these surface changes affect the behaviour of embedded cells when the...Read More
Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)
There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte implantation (MACIs) using a collagen sponge as a chondrocyte delivery vehicle, the sponge membrane alone, and empty controls. A total of three distinct types of...Read More
Change in viability of C2C12 myoblasts under compression, shear and oxidative challengesHong Y, Yao Y, Wong S, Bian L and Mak AFJournal of biomechanics, 49(8), 1305-1310. (2016)
Skeletal and epidermal loadings can damage muscle cells and contribute to the development of deep tissue injury (DTI) – a severe kind of pressure ulcers affecting many people with disability. Important predisposing factors include the multiaxial stress and strain fields in the internal tissues, particularly the vulnerable muscles around bony prominences. A careful study of the mechanical damage thresholds...Read More
Characterization of tissue engineered cartilage products - Recent developments in advanced therapyMaciulaitis J, Rekstyte S, Usas A, Jankauskaite V, Gudas R, Malinauskas M and Maciulaitis RPharmacological Research 113 (2016) 823–832
Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This relates to cell based medicines, such as tissue engineered cartilage products (TECP) which are increasingly developed as new modalities for widely prevalent orthopaedic disorders. Although quality measures for TECP are subject to the same general regulatory quality...Read More
Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576
Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed non-invasive in vivo techniques, such as magnetic resonance elastography. Results of in vitro and in vivo work are compared, emphasizing the specificities...Read More
Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017
Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin s, to characterize cartilage degeneration. This study aims to determine whether the combination of instantaneous, relaxation and equilibrium mechanical properties and friction...Read More
Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive ManufacturingDeng X, Attalla R, Sadowski LP, Chen M, Majcher MJ, Urosev I, Yin D-C, Selvaganapathy PR, Filipe CDM and Hoare TBiomacromolecules 2017, Published Online, doi: 10.1021/acs.biomac.7b01243
We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic crosslinking between 2-aminophenylboronic acid-functionalized hyaluronic acid and poly(vinyl alcohol) yields hydrogels that recover their mechanical integrity within one minute after cutting or shear under both neutral...Read More
Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear.Chen J, Brazile B, Prabhu R, Patnaik SS, Bertucci R, Rhee H, Horstemeyer MF, Hong Y, Williams LN, Liao JJ Biomech Eng. 2018 Jul 1;140(7). doi: 10.1115/1.4039825.
3D轮廓表面形貌测试分析文献：
Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)
Step-off edges and tissue interfaces are prevalent in cartilage injury such as after intra-articular fracture and reduction, and in focal defects and surgical repair procedures such as osteochondral graft implantation. It would be useful to assess the function of injured or donor tissues near such step-off edges and the extent of integration at material interfaces. The objective of this study was to...Read More
Correlation of Non-destructive Electromechanical Probe () Assessment with
Histological Ss, Biochemical Composition and Mechanical Properties in Human Knee JointsSim S, Chevrier A, Quenneville E, Garon M and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, Poster 0439, 2014
2D轮廓测试文献：
Sensitivity of indentation testing to step-off edges and interface integrity in cartilage repairBae W, Law A, Amiel D and Sah RAnn Biomed Eng, 32(3), 360-369. (2004)
Step-off edges and tissue interfaces are prevalent in cartilage injury such as after intra-articular fracture and reduction, and in focal defects and surgical repair procedures such as osteochondral graft implantation. It would be useful to assess the function of injured or donor tissues near such step-off edges and the extent of integration at material interfaces. The objective of this study was to...