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2 medium channels with a 3D mono-culture
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1 medium channel with a 3D co-culture. Here such examples of co-cultures:
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Cancer cells and fibroblasts
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Cancer cells and endothelial cells
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Fibroblasts and endothelial cells
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Cancer cells and macrophages
A relevant example. The in vitro recreation of a perfusable microvascular network represents a challenge in drug discovery and tissue engineering; the IC-Chip may allow you to combine a 3D co-culture of fibroblasts and endothelial cells for the assembly of functional capillaries in vitro through the process of angiogenesis and sprouting. Try it yourself by following the protocol from Kim et al. (Engineering of functional, perfusable 3D microvascular networks on a chip. Lab on a Chip, 2013. 13(8): p. 1489-1500).
Are you looking for a complex pattern with more channels/chambers? The DDI-Chip could fit your needs!
The IC-Chip is a versatile device suitable for a wide range of applications. Find here two assays performed by our satisfied customers:
Cancer cell Invasion & Metastasis
Cell migration and invasion into 3D matrix is important in both health and disease states such as embryonic development and cancer. IC-chip provides an easy-to-use and physiologically relevant microenvironment to directly visualize and quantitatively assess migration and invasion of cells with high temporal and spatial resolution.
PDF file with the complete Application Note & Protocol
Figure 1. Fluorescent cancer cells move through the extracellular matrix following the gradient of chemoattractant. Image courtesy of M. Karabicici and Prof. Esra Erdal.
Figure 2. Time resolution of fluorescent cancer cells migration through the extracellular matrix. Image courtesy of Dr. A. K?s?m and Prof. ?. Yal??n ?zuysal.
Extravasation
Following the creation of a monolayer of endothelial cells it is possible to investigate the invasion and extravasation capacities of cancer cells.
PDF file of the scientific poster
Figure 3. Fluorescently labeled breast cancer cells (MDA -MB -231) interacted with b.End3 endothelial cells and they extravasated through the endothelial monolayer into the matrix channel channel of the IC-Chip. Image courtesy of Prof. Devrim Pesen Okvur.
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Worldwide shipping
We ship worldwide from our warehouse in France.
The shipping charges are calculated based on the weight of the package and the country of destination: you can estimate the shipping cost on the cart page. We try to offer you the best shipping rates and services, shipping all our orders through DHL Express. Generally, your order reaches your lab in only 2 to 3 days after we send it, no matter the destination!
Please note that our shipping incoterms are DAP (Delivered At Place). Please contact us if you prefer using your own courrier account or have any question!
