端到端工作流程

产品详情

• 预先接种的血管。AngioPrime 提供即用型 HUVEC，这些 HUVEC 在 idenTx 40 中沿 3D 胶原凝胶界面预先接种，让您在到达后立即开始检测。
• 标准化细胞来源。hTERT 永生化 HUVEC 保留原代细胞表型，同时确保长期可用性以获得一致的结果。在此处了解有关 hTERT 永生化细胞来源优势的更多信息，并在此处查看比较研究。

• 更高水平的可重复性。我们的团队确保每个产品的质量，将运输温度保持在 4-8°C 之间，以实现可靠的血管生成芽形成。

Selected Publications Using AIM’s Technology

Angiogenesis

1. A streamlined method to generate endothelial cells from human pluripotent stem cells via transient doxycycline-inducible ETV2 activation. Luo, A. C., Wang, J., Wang, K., Zhu, Y., Gong, L., Lee, U., … & Melero-Martin, J. M. (2024). Angiogenesis, 27(4), 779-795.
2. The 3D organ-on-a-chip model unveils a dual role of GDF-15 in vascular growth. Sarad, K., Dulak, J., & Ja?wa-Kusior, A. (2024). Biochemical and Biophysical Research Communications, 733, 150441.
3. 3D Microvascularized Tissue Models by Laser-Based Cavitation Molding of Collagen. Enrico, A., Voulgaris, D., ?stmans, R., Sundaravadivel, N., Moutaux, L., Cordier, A., … & Stemme, G. (2022). Advanced Materials, 34(11), 2109823.
4. Podoplanin is Responsible for the Distinct Blood and Lymphatic Capillaries. Jeong, D. P., Hall, E., Neu, E., & Hanjaya-Putra, D. (2022). Cellular and molecular bioengineering, 15(5), 467-478.
5. Angiogenic Sprouting Dynamics Mediated by Endothelial-Fibroblast Interactions in Microfluidic Systems. Walji, N., Kheiri, S., & Young, E. W. (2021). Advanced Biology, 5(11), 2101080.

Anti-Angiogenesis

1. Exosomal miR-184 in the aqueous humor of patients with central serous chorioretinopathy: a potential diagnostic and prognostic biomarker. Yang, J. M., Kim, S. J., Park, S., Son, W., Kim, A., & Lee, J. (2023). Journal of Nanobiotechnology, 21(1), 242.
2. Antiangiogenic Nanomicelles for the Topical Delivery of Aflibercept to Treat Retinal Neovascular Disease. Zhao, X., Seah, I., Xue, K., Wong, W., Tan, Q. S. W., Ma, X., … & Loh, X. J. (2022). Advanced Materials, 34(25), 2108360.
3. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Park, J. H., Kim, M. J., Kim, W. J., Kwon, K. D., Ha, K. T., Choi, B. T., … & Shin, H. K. (2020). Cancer letters, 478, 71-81.
4. Phthalimide Derivative Shows Anti-angiogenic Activity in a 3D Microfluidic Model and No Teratogenicity in Zebrafish Embryos. Mercurio, A., Sharples, L., Corbo, F., Franchini, C., Vacca, A., Catalano, A., … & Adriani, G. (2019).  Frontiers in pharmacology, 10, 349.

For more publications using our technology to study vascular biology, visit our website publications page.