The following publications contain useful information about SynVivo technology and applications. Follow the doi links to see the abstracts and to obtain copies of the papers. Let us know if you have published a peer reviewed article utilzing SynVivo and we can add it to the list.
A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy. Shantanu Pradhan, Ashley M. Smith, Charles J. Garson, Iman Hassani, Wen J. Seeto, Kapil Pant, Robert D. Arnold, Balabhaskar Prabhakarpandian & Elizabeth A. Lipke. Scientific Reports Volume 8, Article number: 3171(2018)
Trastuzumab Distribution in an In-Vivo and In-Vitro Model of Brain Metastases of Breast Cancer Tori B. Terrell-Hall, Mohamed Ismail Nounou, Fatema El-Amrawy, Jessica I.G. Griffith and Paul R. Lockman Oncotarget. 2017; 8:83734-83744
A Biomimetic Microfluidic Tumor Microenvironment Platform Mimicking the EPR Effect for Rapid Screening of Drug Delivery Systems Yuan Tang, Fariborz Soroush, Joel B. Sheffield, Bin Wang, Balabhaskar Prabhakarpandian & Mohammad F. Kiani Scientific Reports 7, Article number: 9359 (2017)
Permeability across a novel microfluidic blood‑tumor barrier model. Tori B. Terrell‑Hall , Amanda G. Ammer , Jessica I. G. Griffith and Paul R. Lockman Fluids and Barriers of the CNS (2017) 14:3
A novel microfluidic assay reveals a key role for protein kinase C δ in regulating human neutrophil-endothelium interaction. Soroush F, Zhang T, King DJ, Tang Y, Deosarkar S, Prabhakarpandian B, Kilpatrick LE, Kiani MF. J Leukoc Biol November 2016 100:1027–1035.
A Novel Dynamic Neonatal Blood-Brain Barrier on a Chip. S. Deosarkar, B. Prabhakarpandian, B. Wang, J.B. Sheffield, B. Krynska, M. Kiani. PLOS ONE, 2015
Adhesion Patterns in the Microvasculature are Dependent on Bifurcation Angle. G. Lamberti, F. Soroush, A. Smith, M. Kiani, B. Prabhakarpandian, K. Pant. Microvascular Res., 2015, 99, pp 19-25
Expanding Imaging Capabilities for Microfluidics: Applicability of Darkfield Internal Reflection Illumination (DIRI) to Observations in Microfluidics. Y. Kawano, C. Otsuka, J. Sanzo, C. Higgins, T. Nirei, T. Schilling, T. Ishikawa. PLoS ONE, 2015, 10(3): e0116925
Synthetic Tumor Networks for Screening Drug Delivery Systems. B. Prabhakarpandian, MC Shen, J. Nichols, C. Garson, I. Mills, M. Matar, J. Fewell, K. Pant. J Control Release., 2015, 201, 49-55
Bioinspired Microfluidic Assay for In Vitro Modeling of Leukocyte–Endothelium Interactions. G. Lamberti, B. Prabhakarpandian, C. Garson, A. Smith, K. Pant, B. Wang, and M.F. Kiani. Anal. Chem., 2014, 86 (16), pp 8344–8351
Generation of Shear Adhesion Map Using SynVivo Synthetic Microvascular Networks. Smith, A. M., Prabhakarpandian, B., Pant, K. J. Vis. Exp. (87), e51025, 2014
Using shape effects to target antibody-coated nanoparticles to lung and brain endothelium. Kolhara P, Anselmob AC, Guptab V, Pant K, Prabhakarpandian B, Ruoslahtid E, and Mitragotri S. PNAS 2013
Adhesive Interaction of Functionalized Particles and Endothelium in Idealized Microvascular Networks. G. Lamberti, Y. Tang, B. Prabhakarpandian, Y. Wang, K. Pant, M.F, Kiani, B. Wang. Microvascular Res. 2013 (89) pp 107-114
SyM-BBB: A Microfluidic Blood Brain Barrier Model B. Prabhakarpandian, M.-C. Shen, J.B. Nichols, I.R. Mills, M.S.-Wegrzynowicz, M. Aschner, K. Pant, Lab on a Chip, 2013, 13, 1093-1101
Bifurcations: focal points of particle adhesion in microvascular networks. Prabhakarpandian B, Wang Y, Rea-Ramsey A, Sundaram S, Kiani MF, Pant K. Microcirculation. 2011 Jul;18(5):380-9
Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks. Doshi N, Prabhakarpandian B, Rea-Ramsey A, Pant K, Sundaram S, Mitragotri S. J Control Release. 2010 Sep 1;146(2):196-200
Preferential adhesion of leukocytes near bifurcations is endothelium independent. Tousi N, Wang B, Pant K, Kiani MF, Prabhakarpandian B. Microvasc Res. 2010 Dec;80(3):384-8
A physiologically realistic in vitro model of microvascular networks. Rosano JM, Tousi N, Scott RC, Krynska B, Rizzo V, Prabhakarpandian B, Pant K, Sundaram S, Kiani MF. Biomed Microdevices. 2009 May 19
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