匈牙利ThalesNano  www.thalesnano.com
H-Cube(R) 流动加氢催化反应器是一个独立运作的台式加氢催化反应设备。它独树一帜地结合流动化学原理，自带灵活的氢气发生系统以及可处理的催化剂柱。相较过去的传统技术而言，H-Cube(R) 更加安全、迅速、高效及高产。ThalesNano 公司发明的 H-Cube 在内的一系列新型的加氢催化反应器具有缩短研发时间，增加成本效益，以及降低对环境所造成的影响等优势，从而给新药研发过程带来巨大的利益。
ThalesNano is specialized in developing and providing microscale flow instruments for chemistry, by exploiting benefits of combining microfluidics, mesofluidics and nanotechnology with flow chemistry. The company was founded in 2002 and is located in Budapest, Hungary.

The company is widely recognized for its expertise in transforming chemical processes to microscale continuous-flow operations and developing manual or robotic continuous microreactors for the chemical industry.

ThalesNano is a technology-intensive company whose results are strictly founded on its own R&D activities, which directly realize the company’s goals along with newer and newer innovative endeavors. H-Cube® hydrogenation reactor by ThalesNano has been awarded the R&D 100 Award 2005 by R&D Magazine and the Hungarian Industry Innovation Prize in 2005.

The company provides solutions for leading pharmaceutical and biotechnology companies from all over the world.

ThalesNano is also a member of the Hungarian Biotechnology Association.

ThalesNano is a world-leading provider of continuous process technologies and flow chemistry instruments in the rapidly developing market of laboratory and process scale flow reactors.

The company has the widest portfolio of bench-top continuous process instruments. Its H-Cube® continuous-flow hydrogenation reactor and the pilot plant scale version H-Cube Midi™ are used in hundreds of laboratories in four continents and have become the new industry standard for hydrogenation.
Flow chemistry, an emerging technology, allows the rapid optimization and synthesis of organic compounds, including reactions with unrealizable hazardous reaction conditions. Additional benefits are seen in the area of Green Chemistry and lab automation. This technology also promotes the rapid scale-up from mg to kg quantities which in the long run will result in lower CAPEX and OPEX.

The miniaturization of chemical reactors offers many fundamental and practical advantages to the pharmaceutical industry in the synthesis of compounds for high-throughput screening.

Reactions performed in microreactors invariably generate purer products in higher yields and in shorter periods of time than the equivalent batch reactions. Sufficient quantities of product are produced to perform full instrumental characterization. One of the obvious applications of these systems is combinatorial chemistry and drug discovery, where the generation of compounds with either different reagents or under variable conditions is an essential factor. In short, microreactor technology has the potential to revolutionize the pharmaceutical industry because the number of potential drug candidates that can be prepared and screened can be considerably increased. Therefore, the likelihood of developing new drugs is enhanced.

Microreactors are also more convenient and cost-effective than conventional systems. When running the same process in a microreactor array the scaling effort is prevented and fewer personnel are required to operate the continuous process. In a cost comparison calculation, it is assumed that yields are increased and the solvent consumption is reduced thanks to lower thermal buffering requirements.

Combinatorial chemistry and parallel synthesis of new drug candidates in microscale is an untapped area. ThalesNano has worked on this model and has developed a variety of chemical reactions with optimization at several levels. Combining these processes in series enables ThalesNano to perform combinatorial chemistry in a microfluidic environment on an industrial scale.