产品说明
细胞 在两个平行表面之间被均匀地限制/压缩到具有亚微米分辨率的定义微米高度。
提供不同的限制高度（例如 1 ?m – 300 ?m）
允许进行长期细胞培养和细胞增殖，同时保持对限制的完美控制
与高分辨率光学显微镜系统兼容
可以处理足够多的细胞以进行quan基因表达分析
可与生物功能化微结构基材和/或不同基质（几何控制）结合
可与凝胶结合使用（硬度控制）
兼容的 35 毫米培养皿和 6 孔板
如需定制设计，请联系我们
细胞迁移 2.5D、非粘附细胞的迁移和相互作用、细胞挤压、扁平细胞成像（细胞器以 2D 排列）、超分辨率视频显微镜（细胞器移动较少）、收缩性测定等
HeLa 细胞：不受限制，5 ?m、3 ?m。
核裂变和层流破裂受细胞限制程度的调节
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A flagellate-to-amoeboid switch in the closest living relatives of animals
Brunet. T., et al., Elife, 2021 Jan 15;10:e61037
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The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
Venturini. V., et al., Science, 2020, 370, eaba2644
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Confinement and Low Adhesion Induce Fast Amoeboid Migration of Slow Mesenchymal Cells
Y.-J. Liu, M. Piel., et al., Cell, 2015 160(4), 659-672
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Actin flows induce a universal coupling between cell speed and cell persistence
P. Maiuri, R. Voituriez, et al., Cell, 2015 161(2), 374–386
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Geometric friction directs cell migration
M. Le Berre, M. Piel, et al., Physical Review Letter 2013 111, 198101
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Mitotic rounding alters cell geometry to ensure efficient spindle assembly
O. M. Lancaster, B. Baum, et al., Developmental Cell, 2013 25(3), 270-283
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Fine Control of Nuclear Confinement Identifies a Threshold Deformation leading to Lamina Rupture and Induction of Specific Genes
M. Le Berre, J. Aubertin, M. Piel, Integrative Biology, 2012 4 (11), 1406-1414
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Exploring the Function of Cell Shape and Size during Mitosis
C. Cadart, H. K. Matthews, et al., Developmental Cell, 2014 29(2), 159-169
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Methods for Two-Dimensional Cell Confinement
M. Le Berre, M. Piel, et al., 2014, Micropatterning in Cell Biology Part C, Methods in cell biology, 121, 213-29
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