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  • 美国BIOSCIENCETOOLS

    美国shelfscientific微电

    SynVivo血管微环境模拟系统、SynVivo微流控设备系统

    flexcell,flexercell FX-5000T,fx4000细胞牵张拉伸应力加载系统(Flexcell FX5000 Tension system)

    flexcell,flexercell BioFlex,uniflex拉力培养板

    flexcell,flexercell FX-5000C细胞压力加载系统(flexcell FX5000 Compression system)

    flexcell,flexercell FX-5000TT可牵张拉伸刺激立体水凝胶支架三维细胞培养系统(Flexcell TissueTrain System)

    更多

    • Welome to Bio Excellence® international Tech Co.,Ltd.The leading total solution supplier in the life science community.

      Bio Excellence® is a technology leader in providing system solutions for Biosciences,nvironmental and medical research.

      Our expert team of scientists, engineers, and sales professionals have been working in China since 2001. Working closely with the commercial and government scientific communities during the past more than ten years has positioned Bio Excellence® at the forefront of high-tech medical industry.

      Focusing on China, we have earned a deep understanding of the true forces that are behind the rapid modernization in this country. What gives us the edge in China is our priceless and solid network of associates within the private and government research facilities, hospitals, and universities. China is a country that business deals are made through connections and close relationship with the customers. Our mission statement is to support the customer before, during, and after each sale. Once a b and trusted business relationship is established with the customers, they will always remain loyal.

    • Bio Excellence® international Tech Co.,Ltd.is committed to promoting a quality norm for the biotechnology industry in China(include:China Mainland,Hong Kong,Macao,Taiwan). which have been focusing on distributing around the world scientific instruments in China for more than ten years.Bio Excellence® have been looking for foreign manufacturers of scientific equipments for the Chinese researchers, meanwhile open and develop the Chinese market free for you. We are the golden key to open the Chinese market for you.
      We surpass other dealers in the field through our expertise, in part due to our management's b research background and thorough understanding of our customers' needs. We offer timely service and distribute the highest quality goods available in the market. Healthy growth and reputation are the ideas we strive for. In order to achieve these goals, we offer our customers the followings:
      Frequent Information Updates(Need to communicate with customers face to face)
      Timely Delivery
      Swift Service Response
      Sufficient Pre or Post-sale Technical Support
      With the objective of providing the highest quality Pre & Post-sale services to our customers, we regularly send our in-house application scientists and maintenance engineers for overseas trainings arranged by the suppliers. This training is necessary in making sure that we have sufficient technical knowledge to comprehensively answer customers' problems and inquiries efficiently.
      Being a regional distributor to our suppliers, we have undertaken the responsibility of providing an efficient procurement-distribution-fulfillment solution and to arrange promotional activities, such as exhibitions, seminars, workshops, and road shows. Bio Excellence® also maintains very close relationships with the suppliers to provide post-sales services to customers, including technical and application support.
      Apart from distribution, We also engaged in providing medical research consulting and technical services for clinical doctors. Its services include research project design & implementation, data processing & analysis, and research reports summarization.

    • We have employed a professional team led by full-time scientists who used to work in the world-renowned institutions. Our technical team is especially expert in eight areas of research, including medical cell biology, animal disease models, medical molecular biology, medical electrophysiology, medical nano material, medical genetics and bioinformatics, pathology and medical imaging, drug research and development.

    • BIO EXCELLENCE® INTERNATIONAL Tech Co.,Ltd, we have successfully acquired exclusive distributorships in China(include:China Mainland,Hong Kong,Macao,Taiwan) from a number of world-class manufacturers, such as:
      Flexcell
      Tissue Growth
      Biomomentum
      cellscale
      cellixltd
      SKE
      regenHU
      Celltool
      SymCel
      Cellsorter
      nanotherics
      lazarlab
      orflo
      cytoo
      synvivobio
      orflo
      picotwist
      Biospace
      lumicks
      Embitec

    • Mechanobiology
    • Micromanipulator
    • 3D Printer
    • Cellsorter&Analyzer
    • Flexcell® FX-6000™ Tension System (New)



      Feature:Apply equibiaxial or uniaxial tension to cells in 2D or 3D culture,allow the user to observe signaling responses to strain in real time on a microscope stage.
      Uses vacuum pressure and positive air pressure to deform a flexible-bottomed culture plate yielding up to 33% substrate elongation. Mimics in vivo conditions in cells from muscle, lung, heart, vascular vessels, skin, tendon, ligament, cartilage, and bone. Applies a defined, controlled, static or cyclic deformation to cells growing in vitro. Control of the vacuum pump with the FX-6000™ software. Compatible with Windows 10.

      Flexcell Jr. Tension system



      Feature:Apply equibiaxial or uniaxial tension to cells in microscope devices,use Flexcell® StageFlexer® Jr. A compact strain device designed to accept membranes removed from the well of a BioFle®x®, Tissue Train®, or UniFlex® culture plate and observe signaling responses to strain in real time.

      Flexcell cell/tissue Compression System



      Feature:Apply compression to tissue samples or 3-D cell-seeded constructs, use FlexcellFeature StagePresser™--A single-well embodiment of the compression apparatus designed to allow the user to detect signaling responses to compression.

      Flexcell 3D cell and 3D Tissue Train System



      Feature:3-D cell culture in a gel matrix with or without cyclic uniaxial tension,A computer-regulated bioreactor that allows users to create 3-dimensional cell-seeded gels and apply uniaxial tensile strains to these gels.

      FLEXCELL® SCANFLEX™ WITH XYFLEX™



      >Feature:Measure gel compaction in 3-D bioartificial tissues,Automated repetitive scanning process. Scans and saves images of 3-D tissue constructs.User defined frequency and time intervals of image capture. Can be used with the Tissue Train system to determine the compaction kinetics (change in area) of 3-D cell seeded-gels.Scans four 6-well Tissue train culture plates placed on the scanner bed. Images can be imported into Xyflex™ program to analyze area measurement.

      Flexcell Streamer Fluid Shear System



      Feature:Apply fluid shear stress to cells with laminar, pulsatile, or oscillating flow,use Flexcell® FlexFlow™ Shear Stress Device--A shear stress device that allows the user to observe signaling responses to fluid flow and/or apply strain to cells before, during, or after applying a shear stress...

      Biomomentum mach-1 micromechanical testing system



      Mach-1™ is a micromechanical testing system commercially available since 1999. Originally developed for cartilage testing, this multiple-axis tester is used in various configurations to evaluate the mechanical properties of tissues and soft materials. Due to its modular design, small footprint and customization features, the Mach-1™ offers versatility in numerous biological, biomaterial, and material testing applications.

      Biomomentum Arthro-BST™ device



      The hand-held Arthro-BST™ device is used to map electromechanical properties of articular cartilage. The purpose of the study was to evaluate correlation of electromechanical properties with histological, biochemical and biomechanical properties of cartilage

      BISS&TGT 3D LumeGen Vascular Bioreacto



      The DynaGen® Series bioreactors provide mechanical stimulation to three dimensional tissue engineered constructs to create physiological conditions in-vitro. The LumeGen system imparts pulsatile flow and pressure to a vascular conduit. Applications include the investigation of cell function and differentiation, pharmaceutical benchtop testing, and the seeding and growth of engineered tissues and medical devices

      BISS&TGT CardioGen HeartValve Bioreactor



      The DynaGen® Series bioreactors provide mechanical stimulation to three dimensional tissue engineered constructs to create physiological conditions in-vitro. The CardioGen system imparts pulsatile flow and pressure to a valve or valve-like structure. Applications include the investigation of cell function and differentiation, pharmaceutical benchtop testing, and the seeding and growth of engineered tissues and medical devices.

      BISS&TGT LigaGen Ligament and Tendon Bioreactor



      he DynaGen® Series bioreactors provide mechanical stimulation to three dimensional tissue engineered constructs to create physiological conditions in-vitro. The LigaGen system imparts axial stress or strain to a ligament or tendon construct. The stress/strain profiles can be defined by the user and can be a simple harmonic (sinusoidal) or a physiological waveform. Applications include the investigation of cell function and differentiation, pharmaceutical benchtop testing, and the seeding and growth of engineered tissues and medical devices. Researchers are currently utilizing these systems in a wide range of research areas including:1)ACL regenerative medicine.2)Collagen gel stimulation.3)Small diameter tendon stimulation Hand tendon and ligament regenerative medicine

      BISS&TGT OsteoGen Bioreactor



      TGT's OsteoGen bioreactors impart perfusion through cell seeded cylindrical scaffolds. Applications include investigating cell function, modulating the growth and development of engineered tissues, or acting as a test bed for drug and regenerative medicine technologies. Researchers are currently utilizing these systems in a wide range of research areas including:1)Bone stem cell phenotype research2)Mineral deposition of marrowstromal cells

      BISS&TGT CartiGen Cartilage Bioreactor



      The DynaGen® Series bioreactors provide mechanical stimulation to three dimensional tissue engineered constructs to create physiological conditions in-vitro. The CartiGen system imparts compressive or hydrostatic stress to a cartilage construct. The stress/strain profiles can be defined by the user and can be a simple harmonic (sinusoidal) or a physiological waveform. Applications include the investigation of cell function and differentiation, pharmaceutical benchtop testing, and the seeding and growth of engineered tissues and medical devices. Researchers are currently utilizing these systems in a wide range of research areas including:1)Stem cell stimulation. 2)Meniscus regenerative medicine.3)Chondrocyte stimulation

      BISS&TGT DermiGen 3D skin Bioreactor



      The DermiGen bioreactors impart static and oscillatory stimulation to a "skin like" sample in a unique air-to-nutrient media interface. Applications include investigating cell function and stimulating the growth and development of engineered tissues. The device can also be used as a "test bed" for pharmaceutical and regenerative therapies. The DermiGen can apply either stress or strain using operator defined wave forms

    • 1.Optical Stretcher

      Features:
      single cell analysis with laser beams,a novel laser tool to measure and analyse biomechanical properties!The optical stretcher is a novel laser tool to micromanipulate single biological cells and to probe their viscoelastic properties in suspension.Based microfluidic technology for high-throughput analysis of single cell traction and measurement;Automated measurement and imaging properties of single cell force recorded cell deformation record
      1)Contact-free cell deformation
      Contact-free cell deformation” open=”0″ style=”2″]Suspended cells are deformed by optical forces, leading to absolutely contact-free measurements. This ensures homogeneous cell handling and avoids artefacts due to contact-induced cellular reactions.
      2)Timesaving, automated measurements
      Cells are automatically delivered to the measurement region and deformed corresponding to the user-defined stretch pattern. While the Optical Stretcher runs the experiment you can focus on interpreting results.
      3)High-throughput single cell rheology
      By integration of a microfluidic system about 300 cells/hour can be measured with ease. This allows for the first time to collect significant statistical data from cell rheology.
      4)Better statistics compared to AFM
      A cell is trapped by two opposing laser beams, which hold it and pull on both sides of it. Higher laser powers are used to deform the cell. The cell deformations are recorded by a CCD camera and evaluated by a custom designed software. The measurement chamber of the Optical Stretcher is integrated into a microfluidic system, such that cells can be easily delivered one after the other. High throughput rates of about 250 cells per hour can be achieved, allowing for better statistics compared to other tools such as atomic force microscopy (AFM).

      2.Single Molecule Biophysics Magnetic Trap—Stretching and twisting single molecules

      Features:
      PicoTwist is involved in nanomanipulation and single-molecule experiments in biology. Historically, single molecule experiments were among the first nanotechnologies, appearing in the 1990s to characterize biopolymers and proteins with unprecedented accuracy. The idea is that instead of analyzing the behavior of a great number of molecules as usually done in a test tube, you now analyze the behavior of a single molecule. Thus instead of measuring average behavior you have direct access to the biopolymer’s activity in real time.

      3.High-Linearity Single Molecule Atomic Force Spectrometer-Protein Dynamics

      Features:
      The Atomic-Force-Spectrometer (AFS) is an instrument for the study of single proteins placed under a calibrated mechanical load. The AFS is used to understand how mechanical forces, over the full biological spectrum, affect the dynamics and chemistry of proteins. The AFS allows for the picking-up and mechanical manipulation of single recombinant proteins. The AFS instrument was designed to be fully automatic and be able to operate for days, unattended by an operator. Its operating software includes routines that unambiguously identify the mechanical fingerprints of the protein being studied, and thus is able to recognize and store data automatically. At the end of a daylong experiment, it is possible to collect several hundred single-protein traces.

      4.Intra-Cytoplasmic Sperm Injection

      This Set-up was specially developed for the demands of microinjection. With this design we have put a high value on ergonomy, individualization and comfortable operation. All functions have been built the respective Trackball-Keypad with this Set-up, so that a genuine one-hand-operationality exists. The fact should be highlighted that the operation of the manipulator in three dimensions as well as the control of the dosing units (injection, aspiration and holding) is maintained through the Trackball and both function keys. Thereby the operators hand does not need to be raised from the keypad throughout the injection, so that full concentration can be given to the carrying out of the injection.Many other helpful functions enormously assist and speed up the work-process, which is specially noticeable in routine work. Through is high levbel of flexibility this Set-up can be combined or re-arranged at will, and fulfills the most differing expectations. The field of application ranges from ICSI to Transfer to the injection of color-dyes.

    • RegenHU 3Ddiscovery 3D bio-printing platform

      The 3DDiscovery® instrument is a cost-effective 3D bio-printing platform to explore the potential of 3D tissue engineering through the bio-printing approach.

      RegenHU BioFactory® high end, versatile and cell friendly three dimensional bio-manufacturing instrument

      The BioFactory® is a high end, versatile and cell friendly three dimensional bio-manufacturing instrument. It allows researchers to pattern cells, biomolecules and a range of soft and rigid materials in desirable 3D composite structures in order to mimic biomimetic tissue models.

    • Neuroindx UnipicK vacuum-assisted single cell collection and tissue microdissection

      UnipicK is a vacuum-assisted single cell collection and tissue microdissection instrument based on NeuroInDx’s original capillary-based cell and tissue acquisition system (CTAS; USPT 8,797,644; Kudo et al, 2012) that can acquire individual cells from cell cultures and tissues. It permits rapid acquisition of single cells from any untreated cell cultures, providing reliable and affordable means of most sophisticated experimentation. Moreover, the instrument is suitable for individual cell collection and region specific acquisition of subanatomical areas from complex heterogeneous tissues such as the brain. Operation of the system is intuitive and requires minimal training. Cell cultures require no treatment or specific peripherals, thus enabling unmatched flexibility in experimental design and sample collection.
      Perhaps one of the most distinct features is the ability of UnipicK™ to collect live cells for further reculturing and a plethora of downstream functional studies. Both individual fluorescently labeled and morphologically distinct cells can be acquired from any cell cultures or tissue sections. The procedure has been demonstrated from nearly all types of adherent, suspended and 3D cultures, including difficult samples such as primary cells, or individual cells from fresh frozen and sucrose treated complex tissues, such as brain (please, see http://www.youtube.com/user/NDXInc). With live cells viability tests have demonstrated up to 99% after collection, and up to 30 cells per minute may be collected from adherent cultures.
      Notable Features of UnipicK™ include:
      – Simple operation with minimal training
      – Single cell collection from untreated cultures and tissue sections
      – Efficient tissue microdissection
      – High viability of collected cells
      – High quality RNA and protein for downstream – omics studies
      – Flexibility and versatility – fit any inverted microscope
      – Fraction of the cost of any laser assisted microdissection instrument

      UnipicK+ tissue microdissection, single cell acquisition, and deposition platform

      UnipicK+ is a universal platform for tissue microdissection, single cell acquisition, and deposition into the single wells for further molecular analysis or clonal expansion. The main working principle is based on the capillary based vacuum pulse assisted technology (CTAS; Kudo et al, 2012). Developed system can microdissect tissue sections, collect and deposit individual cells from any adherent cultures grown in standard cell culture dishes in as small as 15 nl volume, compatible with various downstream single cell analyses and next generation sequencing. Like UnipicK, the system may be used with a wide range of inverted microscopes. The benefits include cost-efficiency, simple operation, digital interface, complete workflow from single cell isolation to downstream analysis, compatibility with a wide range of inverted microscopes and use of standard plates and culture dishes.

      CellSorter High throughput single cell sorting

      High throughput single cell sorting directly from the Petri dish
      One single cell arrives to each PCR tube
      10 PCR strips containing 80 tubes can be filled in a cycle
      Glass cover slip for testing single cell deposition in situ
      Drop volume less than 1 ul for adherent cells
      Pick up volume of ~1 nl for suspended cells
      15-20 seconds per cell. When collecting multiple cells, sorting speed is 1 cell/second.
      Number of cells picked up in a single run: 1-1000.
      Isolates a subpopulation of live adherent cells expressing fluorescent or luminescent markers
      Both unlabeled and fluorescentcells are recognized by computer vision
      Viable cells after sorting
      Any adherent and non-adherent cell type can be sorted
      Cell culture needs minimal preparation before sorting
      Average sorting process takes only a few minutes
      Multichannel detection using the fluorescent filter setup of the microscope

    • Imaging analysis
    • Sports
      biomechanics
    • Single-Use-
      Bioreactor
    • Turnkey TIRF Microscopy complex

      Turnkey TIRF Microscopy complex is compatible with Nikon, Olympus, Zeiss, and Leica
      1)inverted microscopes. The complex includes:
      2)Prism-based p-TIRFM flow system, and/or
      3)Lightguide-based lg-TIRFM flow system, and/or
      4)Objective-based o-TIRFM flow system
      5)Multi-color computer-controlled illuminator
      6)Low light EMCCD camera Andor iXon or similar
      7)Optional digital fluidics SmartFlow
      8)Optional temperature control system TC-40 – 25-40oC
      9)Optional filter-wheel EW-6 at emission channel
      10)Optional electrochemical control unit EC-1070
      TIRF Labs supplies turnkey TIRFM complex with TIRF Studio software package, which controls
      MCI-7000 illuminator, Andor EMCCD cameras, digital fluidics SmartFlow, temperature control
      TC-40, filter-wheel EW-6, and electrochemical unit EC-1070. Microscope is not included. TIRF
      Labs will collaborate with microscope supplier of your choice to provide seamless integration of
      TIRFM complex with the microscope.
      applications:
      Cell biology studies
      Molecular diagnostics
      Analysis of biomolecular interactions
      Monitoring real-time kinetics of biomolecular interactions
      Real-time TIRF microarrays
      Combined DNA, RNA, protein, and metabolite arrays
      Studies of protein-protein and protein-DNA interactions
      Studies of surface supported membranes
      Lipid rafts studies
      Nanoengineering
      Drug screening
      Lead optimization
      Bioassay development, and more ..

    • Optoelectronic Plethysmography System for the analysis of breathing mechanics

      OEP System measures the volume of the chest wall and its variation during breathing, using reflective and non invasive markers attached to the thoraco-abdominal skin by biadhesive hypoallergenic tape. The three-dimensional positions of the markers are obtained thanks to infrared light video cameras with flashing LED’s.
      OEP System, with the use of advanced algorithms, also measures the different compartments of the chest wall, provides the continuous monitoring of all ventilatory parameters (tidal volume, frequency inspiratory and expiratory times, etc.) and allows to track end-expiratory and end-inspiratory lung volume variations on a breath-by-breath basis.
      OEP System does not require the use of a mouthpiece or any other physical connection to the patient. Patient’s active participation is not required, making it suitable for the use in Intensive Care Units, when the patient is under anesthesia, during sleep, or when the patient is an infant. It is also suitable for prolonged measurements and the calibration of the system is not subject-specific and does not require the execution of any maneuver by the subject.
      OEP System can be combined with any other measurement, such as flow, pressures, gases concentration, EMG, ultrasonography, haemodynamics, sound, etc. For instance, the combination with esophageal and gastric pressure makes it possible to study the dynamics and energetics of respiratory muscles. It can be carried out in different positions (sitting, standing, supine, prone) and applied during situations like rest, exercise, sleep, mechanical ventilation, functional electrical stimulation, phonation, singing and forced oscillation.
      Characteristics
      easy to use and non-invasive for the patient (intensive care, sleep, children...);
      suitable for a prolonged measurement (it doesn’t suffer of drift problems);
      can be performed in any posture (sitting, supine,..) and under any experimental condition (rest, exercise, phonation,..);
      does not require any connection with the patient, like a mouthpiece or a facial mask that could reduce the subject mobility, alter the natural pattern of breathing or introduce additional dead space;
      volume measurement is not influenced by ambient factor (temperature, humidity and gas composition);
      does not require a specific calibration for each patient;
      provides an accurate measurement of the different compartments of the chest wall (pulmonary rib cage, abdominal rib cage, abdomen, eventually split into their right and left parts).

      Real-time 3D motion capture system

      The MotionMonitor®
      The MotionMonitor is a turnkey 3D motion capture system with software for biomechanics research and rehabilitation. It is designed to synchronously collect data from optical trackers, inertial measurement units, EMG sensors, force plates, hand transducers, EEG systems, digital video, event markers and other analog devices, virtual reality, and haptic devices. Data generated from a rich collection of analytical tools are immediately available for playback with graphical displays of all data outputs and stunning 3D computer graphics and subject animations. Real-time measurement and kinematic analysis of the human body's movement, brain activity, eye movement, muscle recruitment, and external forces acting on the body is achieved using the broadest range of hardware available in the market.

    • Superior Mixing and Mass transfer SINGLE-USE BIOREACTOR

      Feature:
      Single-Use Bior eactor for both Micr obial Fermentation and Mammalian cultures.
      Superior Mixing and Mass transfer.
      Cell culture and Microbial Fermentation.
      System supports both microbial fermentation and mammalian cultures.
      Easy process development and seed-train set-up.
      Full measurement and control, including cooling.

      Superior Mixing and Mass transfer SINGLE-USE BIOREACTOR

      Feature:
      Easy to buy, install and use – provides simplicity, less labour intensive and enables fast set up times.
      Simple set up procedure and systems programming – allows cultures to be set up with minimal hands-on time (<30mins)
      Single-use culture bags – eliminates cleaning requirements, cross contamination and minimises down-time.
      Provides highly accurate control conditions including temperature control (15&dreg;C – 45&dreg;C) with built-in chiller – no external chilling/heating equipment needed and gives optimal production of higher ODs of soluble protein.
      Oxygen generation capability (up to 4 litres / minute) – eliminates need, and extra cost, of oxygen gas supply.
      Higher efficiency of oxygen transfer – potential of protein production at higher ODs.
      Efficient airlift technology – delivers very efficient, controllable aeration and mixing, with minimal sheering and eliminating cell settling.
      Higher performance than shaker flasks and comparable performance to steel/glass stirred systems – optimal protein yields with ease of use.
      Connects to bioreactor cell culture bags via autoclavable, reusable sterile filters – minimises running costs.
      Programmable air/enriched air flow rate (1-10 litres per minute) – provides very efficient mixing and aeration to improve protein yields.

    • flexcell Consumables
    • BioPrint material
    • syringepump
    • Human tissue/organ model
    • 1. SynBBB 3D Blood Brain Barrier Model – Real-time visualization of cellular and barrier functionality
      SynVivo’s SynBBB 3D blood brain barrier model recreates the in vivo microenvironment by emulating a histological slice of brain tissue cells in communication with endothelial cells across the blood brain barrier (BBB). Shear-induced endothelial cell tight junctions, which cannot be achieved in the Transwell® model, are easily achieved in the SynBBB model using physiological fluid flow. Formation of tight changes can be measured using biochemical or electrical analysis (assessing changes in electrical resistance) with the SynVivo Cell Impedance Analyzer. Interactions between brain tissue cells and endothelial cells are readily visualized in the SynBBB assay. Transwell models do not allow real-time visualization of these cellular interactions, which are critical for understanding of the BBB microenvironment.
      SynBBB is the only in vitro BBB model that allows:
      ●Accurate in vivo hemodynamic shear stress
      ●Real-time visualization of cellular and barrier functionality
      ●Significant reduction in cost and time
      ●Robust and easy to use protocols


      The SynBBB system is a highly versatile platform for investigation of:
      Tight junction proteins: Determine the levels of tight junction proteins namely zonula occludens, claudins and occludins which regulate the BBB.
      Transporter proteins: Analyze functionality of transporter proteins (e.g. Pgp) in normal and dysfunctional BBB.
      Drug permeability: Evaluate real-time permeability of therapeutics and small molecules across the endothelium of the BBB.
      Inflammation: Understand the underlying mechanisms of inflammatory responses on the regulation of the BBB.
      Cell migration: Visualize and quantify in real-time migration of immune cells across the BBB.
      Omic changes: Perform genomic, proteomic and metabolic analysis on normal and dysfunctional BBB.
      Neurotoxicity: Analyze toxicity effects of chemical, biological and physical agents on the cells of the BBB.
      Neuro-oncology: Investigate effects of the tumor cells on the BBB.
      Depending on your research needs you can select from the “basic” SynBBB model or a “TEER-compatible” SynBBB configuration.
      TEER Compatible SynBBB Configuration with the SynVivo Cell Impedance Analyzer
      Analyze experiments using real-time trans-endothelial electrical resistance (TEER) including real-time imaging, biochemical and molecular biology methodologies.
      2. SynTumor 3D Cancer Model – Recreating the tumor microenvironment
      SynTumor is a 3D tissue model for real-time visualization and quantitative assessment of cell-cell and cell-drug interactions in a physiologically and morphologically realistic tumor microenvironment. The system enables (a) circulation in the microvasculature, (b) transport across the vessel walls, and (c) delivery to the tumors. Starting with scans of vascular networks incorporated with interstitial and tissue/tumor spaces, the SynTumor 3D tissue model creates an in-vitro tumor microenvironment akin to a viable histological slice.
      The SynTumor 3D Cancer model has the following benefits:
      ●Side by side architecture enables quantitative real time visualization
      ●Physiological leaky vasculature with engineered porous structures
      ●Morphologically realistic in vivo based architecture
      ●Physiologically realistic convective and diffusive transport
      ●Microfluidic platform with ultra-low consumable volumes
      Depending on your research needs you can select from the “idealized” or “microvascular” SynTumor 3D Cancer Model configuration.
      3. SynRAM 3D Inflammation Model – Visualize Rolling, Adhesion and Migration in a Single Assay
      The SynRAM™ 3D Inflammation Model from SynVivo has been developed to study the entire inflammation pathway in a realistic and dynamic environment. By recreating a histological slice of co-cultured tissue and/or tumor cells with a lumen of endothelial cells, the SynVivo platform delivers a physiologically realistic model including flow and shear in a platform and enables real-time tracking of rolling, adhesion and migration processes. This model has been successfully validated against in vivo studies showing excellent correlation with rolling velocities, adhesion patterns and migratory processes (Lamberti et al 2014, Soroush et al 2016).

      The SynRAM 3D inflammation model provides a realistic testing environment including:
      ●Physiological shear stress within a microvascular environment
      ●In vivo like vascular morphology with fully enclosed lumen
      ●Co-culture capability for cell-cell interactions
      ●Quantitative real-time rolling, adhesion, and migration data from a single experiment
      SynRAM enables assessment of cellular interactions comprising of rolling, adhesion and migration through multiple cellular layers in one experiment, in real-time, and represents data closely correlated with in vivo results.
      SynRAM’s innovative design overcomes the current limitations inherent in flow chambers or Transwell chamber based assays. Current flow chamber designs are oversimplified, lack the scale and geometry of the microenvironment and cannot model transmigration. Similarly, Transwell chambers do not account for fluid shear and size/topology observed in vivo, the end point measurements of migration are not reproducible and do not provide real-time visualization.
      SynVivo’s proprietary chip designs range from complex in vivo derived microvascular networks (obtained from digitized images) to produce realistic cellular makeup and vascular morphology resulting in varying shear and flow conditions, to simplified idealized networks designed to reproduce the cellular makeup
      4. SynTox 3D Toxicology Model – Organ Specific Physiological Responses
      SynTox is the only commercially available 3D toxicology model with real-time optical monitoring and multi-compartment, multi-cellular architecture and low reagent requirements. Other benefits of this platform are:
      Physiologically realistic morphological, fluidic and 3D cellular conditions
      Universal platform with architecture specific of desired organ
      Significant reduction in cost and time
      Robust and easy to use protocols
      Compatible with standard analytical instruments for both on chip and off chip assays including omic methodologies for systems biology and bioinformatic analysis
      SynTox 3D Toxicology Model recreates the in vivo micro-environment by emulating a histological slice operating in an in vitro Environment.
      Current in vitro platforms are poor predictors of in vivo safety, efficacy and pharmacokinetics of therapeutics owing to significant difference in the test conditions compared to physiological conditions observed in vivo.
      Current in vitro models routinely utilize 2D monolayers or 3D aggregates of cells under static conditions for studying drug toxicity. These models fail to reproduce in vivo physiological features such as morphological size, physiological blood flow and cellular (biological) make-up of the specific organs being investigated. Other microfluidic models employ a membrane-based top-bottom two-compartment architecture, inherently limiting key desired features such as real-time visualization and the ability to simultaneous analyze multi-cellular cultures.