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Flexcll tissue train 3D culture  system

A computer-regulated bioreactor that allows users to create 3-dimensional cell-seeded gels and apply uniaxial tensile strains to these gels.

• Construct tethered, linear, 3-D cell-seeded collagen gels using a trough loader mold device and flexercell® Tissue Train® culture plates with or without cyclic tension
• Apply a load regimen of uniaxial cyclic strain using a flexercell® Tension System and Arctangle® loading posts
• Apply user-defined strain regimens to simulate heart rate, walking, running and other dynamic exercise patterns to tissue constructs
• Build bioartificial tissue samples of skin, tendon, ligament, etc. up to 35 mm in length
• Observe responses of cells cultured in 3-D matrices with phase contrast, fluorescent, or scanning confocal microscopy
• Tissue Train® Culture System is compatible with Windows 10.

flexercell Tissue Train® 3D Culture System is a computer-regulated cell stretching bioreactor system that allows users to create 3-dimensional cell-seeded gels and apply uniaxial or equibiaxial tensile strains to these gels. The Tissue Train® 3D Culture System is a uniaxial system that allows researchers to apply user-defined strain regimens to simulate heart rate, walking, running, and other dynamic exercise patterns to tissue constructs. This will enable you to build bioartificial tissue samples of skin, tendon, ligament, etc. up to 35 mm in length.

Circular Foam Tissue Train® Culture Plate>>More

Create circular 3D cell-seeded gel constructs, while applying a load regimen of equibiaxial cyclic strain using the flexercell® FX-6000™ Tension System.

• Matrix bonded foam anchors for improved cell attachment
• Monitor changes in cell shape, tissue organziation, cell migration, division, gene expression, protein secretion and expression
• Covalently bonded matrix: Untreated, Amino, Collagen (Type I, IV), Elastin, Pronectin (RGD), and Laminin (YISGR)

Cat No                    Description
TTCF-4001U      Circular Foam Culture Plate --Untreated 
TTCF-4001A      Circular Foam Culture Plate --Amino 
TTCF-4001C      Circular Foam Culture Plate --Collagen Type I 
TTCF-4001C(IV)  Circular Foam Culture Plate --Collagen Type IV 
TTCF-4001E      Circular Foam Culture Plate --Elastin 
TTCF-4001P      Circular Foam Culture Plate --ProNectin 
TTCF-4001L      Circular Foam Culture Plate --Laminin

• Available individually or in case quantity of 40 plates

A) Close-up of open cell foam Bar = 1 mm B) Top view of a well in a 6-well Tissue Train® Circular Foam Culture Plate C) Top view of a well with Collagel® matrix solution attached to the foam ring.

flexercell® scanflex® with xyflex®

use to Measure gel compaction in 3-D bioartificial tissues

SCANflex® Automated Scanning Device

XYflex®  Area Measurement Software

Linear Tissue Train® Culture Plate >>More

Works with the Tissue Train® System to create linear, tethered 3D cell-seeded gel constructs and to provide uniaxial cyclic strain to cells in a gel matrix. 

• Apply a load regimen of uniaxial cyclic strain to the 3D cell-seeded gel using Artangle® loading stations and the flexercell® Tissue Train® System
• Mix preferred cell type in 3D collagen gel using a novel Trough Loader mold device
• Available in matrix bonded cerex nylon mesh or urethane polyester foam anchor tabs for improved cell attachment

Cat No           Description
TT-5001U      Tissue Train Culture Plate --Untreated 
TT-5001A      Tissue Train Culture Plate --Amino 
TT-5001C      Tissue Train Culture Plate --Collagen Type I 
TT-5001C(IV)  Tissue Train Culture Plate --Collagen Type IV 
TT-5001E      Tissue Train Culture Plate --Elastin 
TT-5001P      Tissue Train Culture Plate --ProNectin 
TT-5001L      Tissue Train Culture Plate --Laminin 

Cat No           Description
TT-4001U      Tissue Train Culture Plate --Untreated 
TT-4001A      Tissue Train Culture Plate --Amino 
TT-4001C      Tissue Train Culture Plate --Collagen Type I 
TT-4001C(IV)  Tissue Train Culture Plate --Collagen Type IV 
TT-4001E      Tissue Train Culture Plate --Elastin 
TT-4001P      Tissue Train Culture Plate --ProNectin 
TT-4001L      Tissue Train Culture Plate --Laminin 

Works with the Linear Trough Loaders 6-well  and Arctangle® Loading Stations 6-well:

Figure  Linear Trough Loaders 6-well

Molds for creating various shaped 3D cellseeded gel constructs with the Tissue
Train® Culture System .
Comprised of a Lexan plate with 6 individual, removable posts.
Available in linear and trapezoidal shaped molds.
Available in a set of four or as part of a baseplate kit.

Figure  Arctangle® Loading Stations 6-well

• Packaged individually or in case quantity of 40 plates

Trapezoidal Tissue Train® Culture Plate>>More

Works with the Tissue Train® System to create 3D trapezoidal-shaped bioartificial tissue constructs.

• Create 3D collagen gel constructs using a Trapezodial Trough Loader® as a mold device
• Apply a load regimen of uniaxial cyclic strain to the 3D cell-seeded gel using the flexercell® Tissue Train® System
• Matrix bonded nylon mesh or foam anchors for improved cell attachment
• Available individually or case quantity of 40 plates

TTTP-4001U      Trapezoidal TT Culture Plate --Untreated 
TTTP-4001A      Trapezoidal TT Culture Plate --Amino 
TTTP-4001C      Trapezoidal TT Culture Plate --Collagen Type I 
TTTP-4001C(IV)  Trapezoidal TT Culture Plate --Collagen Type IV 
TTTP-4001E      Trapezoidal TT Culture Plate --Elastin 
TTTP-4001P      Trapezoidal TT Culture Plate --ProNectin 
TTTP-4001L      Trapezoidal TT Culture Plate --Laminin 

TTTP-5001U      Trapezoidal TT Culture Plate --Untreated 
TTTP-5001A      Trapezoidal TT Culture Plate --Amino 
TTTP-5001C      Trapezoidal TT Culture Plate --Collagen Type I 
TTTP-5001C(IV)  Trapezoidal TT Culture Plate --Collagen Type IV 
TTTP-5001E      Trapezoidal TT Culture Plate --Elastin 
TTTP-4001P      Trapezoidal TT Culture Plate --ProNectin 
TTTP-5001L      Trapezoidal TT Culture Plate --Laminin

Collagel® and Thermacol® Kits>>More

Collagen gel solution with rapid gelation at 37 C (see Fig. 1 below).

• All components in one kit for creating a 3D cell-seeded bioartificial type I collagen gel (see Fig. 2 below).
• Multiple applications including tissue engineering, migration studies, differentiation, chemotaxis, cell interactions, & matrix interactions.
• Kit contains atelopeptide and telopetide-containing type I collagen, 5X MEM, fetal bovine serum, 1 M hepes, and 0.1 M NaOH.
• Available in three sizes: mini, midi*, and maxi*.

*10% Savings (based on price of purchasing same number of mini kits individually)

Applications of Thermacol®

• 3D Cell Culture - culture cells in Collagel® to create a 3D cell-seeded type I collagen hydrogel.
• Tissue Engineering - use Collagel® with a Tissue Train® culture plate to create bioartificial tissues.
• Mechanical Load - culture cells in 3D then apply mechanical load with the flexercell® Tension or Compression System.
• Drug Discovery - culturing cells in a 3D environment better mimics in vivo conditions and thus provides a platform to study the effects of various pharmacological agents on cells in a more natural environment.

Bioartificial tissue development with Thermacol® and the Tissue Train® Culture System.