biomomentum 3D软骨剪切力测试分析系统, Shear Test on an Articular Cartilage Disc,关节软骨盘剪切试验系统

型号:mach-1多轴向机械力特性测试分析系统
联系人:李先生
联系电话:18618101725
品牌:加拿大biomomentum

biomomentum 3D软骨剪切力测试分析系统, Shear Test on an Articular Cartilage Disc,关节软骨盘剪切试验系统





MACH-1系统结构图:


( 使用Mach-1  Mechanical Tester - Compression, Shear and Torsion)

(Mach-1 Mechanical Tester - Shear Test on an Articular Cartilage Disc,关节软骨盘剪切试验)

背景:


mach-1系统的支架的底面上具有两个平行设置的承台,两个夹持装置分别设置在两个承台上。通过旋转调节阀就可以使其中的一个夹持装置升降,夹持装置产生纵向的相对位移,使两个夹持装置所夹持的腰椎间盘、软骨等样品产生剪切应力,从而应用于研究剪切应力与椎间盘退变之间的关系,应用于研究剪切应力与椎间盘、软骨等退变之间的关系,可以压缩、剪切、牵张、扭转。



剪切:

剪切试验可用于评估材料在平面剪切或扭转中的剪切模量G. 剪切模量表示当力沿平行于其运动的方向施加而其基部保持静止时材料的刚度。 平衡剪切模量G被描述为剪切应变下的剪切应力。 通常使用两种配置来确定剪切模量:平面剪切,其遵循水平轴(x或y轴),以及扭转剪切,其遵循旋转轴。 在平面剪切的配置下,假设样品是完美的矩形棱柱,其中一个表面处于应力下并且其相对表面受到约束。 在扭转剪切的配置下,假设样品是完美的圆柱体(惯性矩修正可以应用于其他形状),其顶部和底部表面完美地连接到两个压板(非滑动边界条件)。




机械刺激-剪切(MECHANICAL STIMULATION -SHEAR)

已经证明机械响应细胞构建体的剪切刺激对细胞活性具有重要影响,特别是对细胞外基质组分的产生。 这种机械刺激通常在细胞培养期间进行。 Biomomentum的机械测试仪可以在干燥模式下安装在标准培养箱中。 已针对此特定应用设计了封闭式测试室。 在由与细胞培养相容的材料制成的腔室内直接控制湿度和气体水平。

(Mach-1  - 牙齿刷牙模拟器中牙膏的评估视频)


搭接剪切(LAP SHEAR)


与剥离测试一样,搭接剪切对于粘合剂的机械表征非常重要。 在该测试配置中,通过粘合剂粘合在一起的两层材料被迫彼此滑动(没有剥离),从而在粘合剂层中引起剪切并最终破裂。 粘合剪切模量可通过多种测试方法表征。 两种常用的方法是搭接(测试平面剪切以找到剪切模量和剪切强度)和对接(测试拉伸屈服,以找到剪切模量和弹塑性参数)。 平面剪切试验意味着移动压板在与粘合相同的平面内移动。 在这些配置下,假设样品是一个完美的矩形,其顶部和底部表面完美地连接到两个平面基板上(非滑动边界条件),尽管这种配置也可以记录力与滑移的位移数据 物理粘附。




mach-1多轴机械特性测试分析系统






典型测试材料:



功能配置:



研究案例:

  • ©Biomomentum Inc.


相关文献案例:


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Determining the modulus of intact bovine vertebral cancellous bone tissue: Development and validation of a protocolEngbretson ACMaster thesis Queen's University. (2010)
Cancellous, or spongy, bone accounts for nearly 80% of the human skeleton’s internal surface area, despite comprising only 20% of its mass. It is made up of a network of struts and plates that provide lightweight internal support to mammalian...
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Tuning the Microenvironment: Click-Crosslinked Hyaluronic Acid-Based Hydrogels Provide a Platform for Studying Breast Cancer Cell InvasionFisher SA, Anandakumaran PN, Owen SC and Shoichet MSAdv. Funct. Mater. 2015. DOI: 10.1002/adfm.201502778
A big challenge in cell culture is the non-natural environment in which cells are routinely screened, making in vivo phenomena, such as cell invasion, difficult to understand and predict. To study cancer cell invasion, extracellular matrix (ECM)...
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Development of scaffold-free elastic cartilaginous constructs with structural similarities to auricular cartilageGiardini-Rosa R, Joazeiro PP, Thomas K, Collavino K, Weber J and Waldman SDTissue Engineering Part A. Volume 20, Numbers 5 and 6, 2014, pp 1012-26 (2014)
External ear reconstruction with autologous cartilage still remains one of the most difficult problems in the fields of plastic and reconstructive surgery. As the absence of tissue vascularization limits the ability to stimulate new tissue growth,...
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Injectable Interpenetrating Network Hydrogels via Kinetically Orthogonal Reactive Mixing of Functionalized Polymeric PrecursorsGilbert T, Smeets NMB and Hoare TACS Macro Letters, 2015, 4, 1104-1109.
The enhanced mechanics, unique chemistries, and potential for domain formation in interpenetrating network (IPN) hydrogels have attracted significant interest in the context of biomedical applications. However, conventional IPNs are not directly...
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Evaluation of a bioabsorable polylactide film in a large animal model for the reduction of retrosternal adhesionsIliopoulos J, Cornwall G, Evans R, Manganas C, Thomas K, Newman D and Walsh WJournal of Surgical Research, 118(2), 144-153. (2004)
OBJECTIVES: An adult pig model of retrosternal adhesion formation via an inferior hemisternotomy was used to evaluate the formation and development of pericardial and retrosternal adhesions, as well as adhesion reduction using two thicknesses...
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The Aortic Wrap Procedure - A Surgical Method of Treating Age-Related Aortic Dilatation and StiffnessIliopoulos JPhD Thesis, University of New South Wales, Sydney. (2006)
Introduction: There is progressive stiffening and dilatation of the aorta and large elastic arteries with aging as a result of the repetitive cyclic stress they are exposed to throughout life. Aortic stiffening has a number of detrimental...
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Shear mechanics of the TMJ disc - relationship to common clinical observationsJuran CM, Dolwick MF, and McFetridge PSJ Dent Res. 2013 Feb, 92(2):193-8.
The temporomandibular joint (TMJ) is a complex hinge and gliding joint that induces significant shear loads onto the fibrocartilage TMJ disc during jaw motion. The purpose of this study was to assess regional variation in the disc's shear loading...
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Micro-CT visualization and indentation properties of whole meniscus following mercury exposureKolaczek S, Changoor A, Hurtig M, Gordon K and Getgood AAnnual Meeting of the ORS, New Orleans, Louisiana, USA, March 15-18, 2014.
A major risk factor for knee osteoarthritis (OA) is meniscal injury or excision. Surgeons now advocate for meniscal repair or allografts rather than excision with this knowledge in hand. Clinical assessment of the meniscal load sharing is limited...
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Engineering of Hyaline Cartilage with a Calcified Zone Using Bone Marrow Stromal CellsLee WD, Hurtig MB, Pilliar RM, Stanford WL and Kandel RAOsteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.010
In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the...
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Soft Tissue Phantoms for Realistic Needle Insertion - A Comparative StudyLeibinger A, Forte AE, Tan Z, Oldfield MJ, Beyrau F, Dini D and Rodriguez y Baena FAnnals of Biomedical Engineering. pp 1-11 (2015)
Phantoms are common substitutes for soft tissues in biomechanical research and are usually tuned to match tissue properties using standard testing protocols at small strains. However, the response due to complex tool-tissue interactions can differ...
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Characterization of the effect of microfracture surgery and angle of incidence on the structural properties of femoral boneLiang LD, Wagner A, Steeds J, Hurtig M and Gordon KStudies by Undergraduate Researchers at Guelph, 7(1), 56-61. (2013)
Microfracture surgery is one of the most common treatment options for knee osteoarthritis, a chronic inflammatory disease of the knee joint. However, a recent study by Theodoropoulos et al. (2012) has shown that there are significant variations in...
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Effects of demineralized bone matrix on tendon-bone healing in an intra-articular rodent modelLovric V, Chen D, Yu Y, Oliver RA, Genin F and Walsh WRThe American journal of sports medicine, 40(10), 2365-2374. (2012)
BACKGROUND: Techniques to improve and accelerate tendon-bone healing could be advantageous in anterior cruciate ligament (ACL) reconstruction. Effects of demineralized bone matrix (DBM) on intra-articular tendon-bone healing have not been...
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The effect of terminal sterilization on structural and biophysical properties of a decellularized collagen-based scaffold; implications for stem cell adhesionMatuska AM and McFetridge PSJ Biomed Mater Res Part B, 2014, pp 1-10
Terminal sterilization induces physical and chemical changes in the extracellular matrix (ECM) of ex vivo-derived biomaterials due to their aggressive mechanism of action. Prior studies have focused on how sterilization affects the mechanical...
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Biomechanical and biochemical outcomes of porcine temporomandibular joint disc deformationMatuska AM, Muller S, Dolwick MF and McFetridge PSArchives of Oral Biology. 64, 2016, 72–79
Objective: The structure–function relationship in the healthy temporomandibular joint (TMJ) disc has been well established, however the changes in dysfunctional joints has yet to be systematically evaluated. Due to the poor understanding of...
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In vivo dynamic loading reduces bone growth without histomorphometric changes of the growth plateMenard AL, Grimard G, Valteau B, Londono I, Moldovan F and Villemure IJ Orthop Res. 2014 Sep;32(9):1129-36. doi: 10.1002/jor.22664. Epub 2014 Jun 6.
This in vivo study aimed at investigating the effects of dynamic compression on the growth plate. Rats (28 days old) were divided into three dynamically loaded groups, compared with two groups (control, sham). A device was implanted on the 6th and...
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Static and Dynamic Compression Application and Removal on the Intervertebral Discs of Growing RatsMenard AL, Grimard G, Massol E, Londono I, Moldovan F and Villemure IJournal of Orthopaedic Research Month 2015, pp.1-9. (2015)
Fusionless implants are used to correct pediatric progressive spinal deformities, most of them spanning the intervertebral disc. This study aimed at investigating the effects of in vivo static versus dynamic compression application and removal on...
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Bone growth resumption following in vivo static and dynamic compression removals on ratsMenard AL, Grimard G, Londono I, Beaudry F, Vachon P, Moldovan F and Villemure IBone. 81 pp. 662-8 doi: 10.1016/j.bone.2015.09.013. (2015)
Mechanical loadings influence bone growth and are used in pediatric treatments of musculoskeletal deformities. This in vivo study aimed at evaluating the effects of static and dynamic compression application and subsequent removal on bone growth,...
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Hyaluronic acid click hydrogels emulate the extracellular matrixOwen SC, Fisher SA, Tam RY, Nimmo CM and Shoichet MSLangmuir, 29(24), 7393-7400. (2013)
Hydrogels are used to create 3D microenvironments with properties that direct cell function. The current study demonstrates the versatility of hyaluronic acid (HA)-based hydrogels with independent control over hydrogel properties such as mechanics,...
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The shear mechanical properties of diabetic and non-diabetic plantar soft tissuePai S and Ledoux WRJournal of biomechanics, 45(2), 364-370. (2012)
Changes in the plantar soft tissue shear properties may contribute to ulceration in diabetic patients, however, little is known about these shear parameters. This study examines the elastic and viscoelastic shear behavior of both diabetic and...
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Longitudinal Stent Deformation: Importance of Stent Type and Stent AppositionPitne, M, van Niekerk E, Dokos S, Pelletier M and Walsh WRAmerican Journal of Biomedical Engineering, 3(3), 63-69. (2013)
Information on stent longitudinal strength is limited to benchtop models using unconstrained stents, consequently having uncertain clinical significance. This study investigated the effects of stent apposition and tube (artery) compliance on stent...
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Low Magnitude High Frequency Vibration Accelerated Cartilage Degeneration but Improved Epiphyseal Bone Formation in Anterior Cruciate Ligament Transect Induced Osteoarthritis Rat ModelQin J, Chow S KH, Guo A, Wong WN., Leung KS and Cheung WHOsteoarthritis and Cartilage. July 2014, Vol.22(7):1061–1067. (2014)
Objectives: To evaluate the effects of low-magnitude high-frequency vibration (LMHFV) on degenerated articular cartilage and subchondral bone in anterior cruciate ligament transection (ACLT) induced osteoarthritis (OA) rat model. 
Growth Factor Stimulation Improves the Structure and Properties of Scaffold-Free Engineered Auricular Cartilage ConstructsRosa RG, Joazeiro PP, Bianco J, Kunz M, Weber JF, et alPLoS ONE 9(8): e105170. doi:10.1371/journal.pone.0105170. (2014)
The reconstruction of the external ear to correct congenital deformities or repair following trauma remains a significant challenge in reconstructive surgery. Previously, we have developed a novel approach to create caffold-free, tissue engineering...
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Tissue engineered nucleus pulposus tissue formed on a porous calcium polyphosphate substrateSeguin CA, Grynpas MD, Pilliar RM, Waldman SD and Kandel RASpine, 29(12), 1299-1306. (2004)
STUDY DESIGN: This study describes the formation of nucleus pulposus tissue using a novel tissue engineering approach. OBJECTIVES: To determine if a construct composed of nucleus pulposus tissue on the surface of a calcium polyphosphate...
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Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null miceSuen RS, Rampersad SN, Stewart DJ and Courtman DWThe American journal of pathology, 179(3), 1549-1559. (2011)
Because both endothelin-1 (ET-1) and angiotensin II (AngII) are independent mediators of arterial remodeling, we sought to determine the role of ET receptor inhibition in AngII-accelerated atherosclerosis and aortic aneurysm formation. We...
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Elastic modulus of 316 stainless steel lattice structure fabricated via binder jetting processTang Y, Zhou Y, Hoff T, Garon M and Zhao FYMaterials Science and Technology 32(7):1743284715Y.000 · June 2015 DOI: 10.1179/1743284715Y.0000000084
This study mainly evaluates the elastic modulus of 316 stainless steel lattice structures fabricated via binder jetting process. In this present research, both solid and lattice samples are designed and fabricated by binder jetting process for two...
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Experimental Evidence of Mechanical Isotropy in Porcine Lung ParenchymaWeed B, Patnaik S, Rougeau-Browning M, Brazile B, Liao J, Prabhu R and Williams LNMaterials 2015, 8 , 2454-2466; doi:10.3390/ma8052454
Pulmonary injuries are a major source of morbidity and mortality associated with trauma. Trauma includes injuries associated with accidents and falls as well as blast injuries caused by explosives. The prevalence and mortality of these injuries has...
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Injectable Interpenetrating Network Hydrogels via Kinetically Orthogonal Reactive Mixing of Functionalized Polymeric PrecursorsTrevor G, Niels M. B. Smeets and Hoare TACS Macro Letters, September 16, 2015, 1104–9. doi:10.1021/acsmacrolett.5b00362
The enhanced mechanics, unique chemistries, and potential for domain formation in interpenetrating network (IPN) hydrogels have attracted significant interest in the context of biomedical applications. However, conventional IPNs are not directly...
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Defective Bone Mineralization and Osteopenia in Young Adult Fgfr3-/- MiceValverde-Franco G, Liu H, Davidson D, Chai S, Valderrama-Carvajal H, Goltzman D, Ornitz DM and Henderson JEHum Mol Genet, 13(3), 271-284
Mutations that cause constitutive activation of fibroblast growth factor receptor 3 (FGFR3) result in skeletal disorders that are characterized by short-limbed dwarfism and premature closure of cranial sutures. In previous work, it was shown that...
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Defects in articular cartilage metabolism and early arthritis in fibroblast growth factor receptor 3 deficient miceValverde-Franco G, Binette JS, Li W, Wang H, Chai S, Laflamme F, Tran-Khanh N, Quenneville E, Meijers T, Poole AR, Mort JS, Buschmann MD and Henderson JEHuman molecular genetics, 15(11), 1783-1792. (2006)
Fibroblast growth factor (FGF) receptor 3 has been identified as a key regulator of endochondral bone development and of post-natal bone metabolism through its action on growth plate chondrocytes and osteoblasts, respectively. It has also been shown...
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Stochastic resonance is a method to improve the biosynthetic response of chondrocytes to mechanical stimulationWeber JF and Waldman SDJournal of Orthopaedic Research 08/2015; DOI:10.1002/jor.23000
Cellular mechanosensitivity is an important factor during the mechanical stimulation of tissue engineered cartilage. While the application of mechanical stimuli improves tissue growth and properties, chondrocytes also rapidly desensitize under...
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The Effects of Oxidative Stress on the Compressive Damage Thresholds of C2C12 Mouse Myoblasts: Implications for Deep Tissue InjuryYao Y, Xiao Z, Wong S, Hsu YC, Cheng T, Chang CC, Bian L and Mak AFAnn Biomed Eng. 2015 Feb;43(2):287-96. doi: 10.1007/s10439-014-1239-6. Epub 2015 Jan 6.
Deep tissue injury (DTI) is a severe kind of pressure ulcers formed by sustained deformation of muscle tissues over bony prominences. As a major clinical issue, DTI affects people with physical disabilities, and is obviously related to the...
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Experimental Investigation of Mechanical and Thermal Properties of Silica Nanoparticle-Reinforced Poly(acrylamide) Nanocomposite HydrogelsZaragoza J, Babhadiashar N, O’Brien V, Chang A, Blanco M, Zabalegui A, H Lee and Asuri PPLoS ONE 10(8): e0136293. doi:10.1371/journal. pone.0136293. (2015)
Current studies investigating properties of nanoparticle-reinforced polymers have shown that nanocomposites often exhibit improved properties compared to neat polymers. However, over two decades of research, using both experimental studies and...
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Infarcted rat myocardium: Data from biaxial tensile and uniaxial compressive testing and analysis of collagen fibre orientationSirry MS, Butler JR, Patnaik SS, Brazile B, Bertucci R, Claude A, McLaughlin R, Davies NH and Liao JData in Brief 8 (2016) 1338–1343
Myocardial infarction was experimentally induced in rat hearts and harvested immediately, 7, 14 and 28 days after the infarction induction. Anterior wall infarct samples underwent biaxial tensile and uniaxial compressive testing. Orientation of...
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A composite hydrogel for brain tissue phantomsForte AE, Galvan S, Manieri F,y Baena FR and Dini DMaterials & Design, 112, 227-238 (2016)
Synthetic phantoms are valuable tools for training, research and development in traditional and computer aided surgery, but complex organs, such as the brain, are difficult to replicate. Here, we present the development of a new composite hydrogel...
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Biomechanical Characterisation of the Human Auricular Cartilage - Implications for Tissue EngineeringGriffin MF, Premakumar Y, Seifalian M, Szarko and Butler PEMAnnals of Biomedical Engineering, 2016. Punlished online, 14Jul2016. DOI: 10.1007/s10439-016-1688-1
Currently, autologous cartilage provides the gold standard for auricular reconstruction. However, synthetic biomaterials offer a number of advantages for ear reconstruction including decreased donor site morbidity and earlier surgery. Critical to...
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Impact of storage conditions on electromechanical, histological and histochemical properties of osteochondral allograftsMickevicius T, Pockevicius A, Kucinskas A, Gudas R, Maciulaitis J, Noreikaite A and Usas ABMC Musculoskeletal Disorders, 16(1), 314. (2015)
Background: Osteochondral allograft transplantation has a good clinical outcome, however, there is still debate on optimization of allograft storage protocol. Storage temperature and nutrient medium composition are the most critical factors...
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Electromechanical Assessment of Human Knee Articular Cartilage with Compression-Induced Streaming PotentialsBecher C, Ricklefs M, Willbold E, Hurschler C, and Abedian RCartilage, 7(1) 62-69. (2016)
To assess the electromechanical properties of human knee articular cartilage with compression-induced streaming potentials for reliability among users and correlation with macroscopic and histological evaluation tools and sulfated glycosaminoglycan...
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25th Anniversary Article: Engineering Hydrogels for BiofabricationMalda J, Visser J, Melchels FP, Jüngst T, Hennink WE, Dhert WJA, Groll J and Hutmacher DWAdv. Mater., 25: 5011–5028. doi:10.1002/adma.201302042 (2013)
With advances in tissue engineering, the possibility of regenerating injured tissue or failing organs has become a realistic prospect for the first time in medical history. Tissue engineering - the combination of bioactive materials with cells to...
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Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011
Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease,...
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A fibril-network-reinforced biphasic model of cartilage in unconfined compressionSoulhat J, Buschmann MD and Shirazi-Adl AJournal of Biomechanical Engineering, Jun, 121(3), 340-347. (1999)
Cartilage mechanical function relies on a composite structure of a collagen fibrillar network entrapping a proteoglycan matrix. Previous biphasic or poroelastic models of this tissue, which have approximated its composite structure using a...
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Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21
OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. In the boundary mode of lubrication, load is supported by surface-to-surface contact, a feature that makes this mode...
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Characterization of tissue engineered cartilage products - Recent developments in advanced therapyMaciulaitis J, Rekstyte S, Usas A, Jankauskaite V, Gudas R, Malinauskas M and Maciulaitis RPharmacological Research 113 (2016) 823–832
Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This relates to cell based medicines, such as tissue engineered cartilage products (TECP) which are increasingly...
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Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576
Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed...
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